Entropic contribution to the linking coefficient in fragment based drug design: a case study
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Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexesNMR approaches in structure-based lead discovery: recent developments and new frontiers for targeting multi-protein complexesProbing water-protein contacts in a MMP-12/CGS27023A complex by nuclear magnetic resonance spectroscopy.Higher throughput calorimetry: opportunities, approaches and challenges.Fragment-based drug discovery using NMR spectroscopyProtein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.Ligand-induced protein mobility in complexes of carbonic anhydrase II and benzenesulfonamides with oligoglycine chainsTwenty years on: the impact of fragments on drug discovery.Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases.The impact of binding thermodynamics on medicinal chemistry optimizations.Critical Evaluation of Native Electrospray Ionization Mass Spectrometry for Fragment-Based Screening.Compound Design by Fragment-Linking.Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.The good, the bad and the twisted: a survey of ligand geometry in protein crystal structures.An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences.Prediction of Positions of Active Compounds Makes It Possible To Increase Activity in Fragment-Based Drug Development.Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.SSNMR of biosilica-entrapped enzymes permits an easy assessment of preservation of native conformation in atomic detailPairwise binding competition experiments for sorting hub-protein/effector interaction hierarchy and simultaneous equilibria
P2860
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P2860
Entropic contribution to the linking coefficient in fragment based drug design: a case study
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Entropic contribution to the l ...... ased drug design: a case study
@ast
Entropic contribution to the l ...... ased drug design: a case study
@en
Entropic contribution to the l ...... ased drug design: a case study
@nl
type
label
Entropic contribution to the l ...... ased drug design: a case study
@ast
Entropic contribution to the l ...... ased drug design: a case study
@en
Entropic contribution to the l ...... ased drug design: a case study
@nl
prefLabel
Entropic contribution to the l ...... ased drug design: a case study
@ast
Entropic contribution to the l ...... ased drug design: a case study
@en
Entropic contribution to the l ...... ased drug design: a case study
@nl
P50
P3181
P356
P1476
Entropic contribution to the l ...... ased drug design: a case study
@en
P2093
Niko Sarti
Valentina Borsi
P304
P3181
P356
10.1021/JM901723Z
P407
P577
2010-05-27T00:00:00Z