Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1 - Test2 - elhamkhani - TriplyDB

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

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Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design Catching HIV 'in the act' with 3D electron microscopy Antigenic properties of the human immunodeficiency virus envelope glycoprotein gp120 on virions bound to target cells Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1 Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1 Structural Analysis of Human and Macaque mAbs 2909 and 2.5B: Implications for the Configuration of the Quaternary Neutralizing Epitope of HIV-1 gp120 Cross-neutralization of influenza A viruses mediated by a single antibody loop A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans Reshaping Antibody Diversity Functional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIV Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor Recent Progress toward Engineering HIV-1-Specific Neutralizing Monoclonal Antibodies Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Survivors Remorse: antibody-mediated protection against HIV-1.Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies.Recent advances on the use of structural biology for the design of novel envelope immunogens of HIV-1 Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodies.Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1.Identification of nitrated immunoglobulin variable regions in the HIV-infected human brain: implications in HIV infection and immune response."Rational vaccine design" for HIV should take into account the adaptive potential of polyreactive antibodies.Autoreactivity in HIV-1 broadly neutralizing antibodies: implications for their function and induction by vaccination.Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection.Immunotypes of a quaternary site of HIV-1 vulnerability and their recognition by antibodies Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C.Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes.Neutralisation of HIV-1 cell-cell spread by human and llama antibodies.Structure-guided alterations of the gp41-directed HIV-1 broadly neutralizing antibody 2F5 reveal new properties regarding its neutralizing function.Accessing of recombinant human monoclonal antibodies from patient libraries by eukaryotic ribosome display.Rapid conformational epitope mapping of anti-gp120 antibodies with a designed mutant panel displayed on yeast Neutralizing Monoclonal Antibodies to Fight HIV-1: On the Threshold of Success.Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity.

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Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

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2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Structure and function of broa ...... potent neutralization of HIV-1

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Structure and function of broa ...... potent neutralization of HIV-1

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Structure and function of broa ...... potent neutralization of HIV-1

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type

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Structure and function of broa ...... potent neutralization of HIV-1

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Structure and function of broa ...... potent neutralization of HIV-1

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Structure and function of broa ...... potent neutralization of HIV-1

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Structure and function of broa ...... potent neutralization of HIV-1

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Structure and function of broa ...... potent neutralization of HIV-1

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Structure and function of broa ...... potent neutralization of HIV-1

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PNAS.1004600107

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Proceedings of the National Academy of Sciences of the United States of America

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Structure and function of broa ...... potent neutralization of HIV-1

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Dennis R Burton

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Laura M Walker

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Robert Pejchal

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Robyn L Stanfield

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Sanjay K Phogat

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Wayne C Koff

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P2860

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120

Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

Molecular architecture of native HIV-1 gp120 trimers

Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site

A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

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10.1073/PNAS.1004600107

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25

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107

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Ian Andrew Wilson

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2010-06-22T00:00:00Z

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44660125

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20534513

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