Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
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HIV-Host Interactions: Implications for Vaccine DesignVaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A VirusesTrimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and GSomatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing AntibodiesCross-Neutralizing Antibodies in HIV-1 Individuals Infected by Subtypes B, F1, C or the B/Bbr Variant in Relation to the Genetics and Biochemical Characteristics of the env GeneWhat Are the Most Powerful Immunogen Design Vaccine Strategies?Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies.A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure.Effect of Glycosylation on an Immunodominant Region in the V1V2 Variable Domain of the HIV-1 Envelope gp120 Protein.Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1.Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaquesDetection of Broadly Neutralizing Activity within the First Months of HIV-1 Infection.Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies.SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts.HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.Epitope-Independent Purification of Native-Like Envelope Trimers from Diverse HIV-1 Isolates.Optimal immunization cocktails can promote induction of broadly neutralizing Abs against highly mutable pathogens.Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop.Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodiesNative-like Env trimers as a platform for HIV-1 vaccine design.Ontogeny-based immunogens for the induction of V2-directed HIV broadly neutralizing antibodies.Germline-targeting immunogens.Antigenic landscape of the HIV-1 envelope and new immunological concepts defined by HIV-1 broadly neutralizing antibodies.Approaches to the induction of HIV broadly neutralizing antibodies.Evolution of B cell analysis and Env trimer redesign.Polyvalent vaccine approaches to combat HIV-1 diversityAntibody-virus co-evolution in HIV infection: paths for HIV vaccine development.Identification and specificity of broadly neutralizing antibodies against HIVTowards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection.How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice.Prospecting for an HIV vaccine.Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic miceDesign and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development.Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model.HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage.
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P2860
Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
description
2016 nî lūn-bûn
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2016 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Structures of HIV-1 Env V1V2 w ...... ies that enable vaccine design
@ast
Structures of HIV-1 Env V1V2 w ...... ies that enable vaccine design
@en
Structures of HIV-1 Env V1V2 w ...... ies that enable vaccine design
@nl
type
label
Structures of HIV-1 Env V1V2 w ...... ies that enable vaccine design
@ast
Structures of HIV-1 Env V1V2 w ...... ies that enable vaccine design
@en
Structures of HIV-1 Env V1V2 w ...... ies that enable vaccine design
@nl
prefLabel
Structures of HIV-1 Env V1V2 w ...... ies that enable vaccine design
@ast
Structures of HIV-1 Env V1V2 w ...... ies that enable vaccine design
@en
Structures of HIV-1 Env V1V2 w ...... ies that enable vaccine design
@nl
P2093
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Structures of HIV-1 Env V1V2 w ...... ies that enable vaccine design
@en
P2093
Adrian B McDermott
Aliaksandr Druz
Baoshan Zhang
Brandon J DeKosky
George Georgiou
Gwo-Yu Chuang
Ivelin S Georgiev
Jonathan Stuckey
Kelly K Lee
M Gordon Joyce
P2860
P2888
P3181
P356
10.1038/NSMB.3144
P50
P577
2016-01-01T00:00:00Z
P6179
1048836415