A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape
about
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesisRNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory MechanismsViral quasispecies evolutionStructures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contactsThe Crystal Structure of a Cardiovirus RNA-Dependent RNA Polymerase Reveals an Unusual Conformation of the Polymerase Active SiteMutagenic Effects of Ribavirin on Hepatitis E Virus-Viral Extinction versus Selection of Fitness-Enhancing MutationsCoronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeuticsNorovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo.Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.Genomic mutation rates that neutralize adaptive evolution and natural selectionRepeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells.Mutagenesis-mediated decrease of pathogenicity as a feature of the mutant spectrum of a viral population.Ultra-deep pyrosequencing of partial surface protein genes from infectious Salmon Anaemia virus (ISAV) suggest novel mechanisms involved in transition to virulence.Effects of ribavirin on the replication and genetic stability of porcine reproductive and respiratory syndrome virusLethal mutagenesis: targeting the mutator phenotype in cancer.Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir.Viral population dynamics and virulence thresholdsThe Attenuation Phenotype of a Ribavirin-Resistant Porcine Reproductive and Respiratory Syndrome Virus Is Maintained during Sequential Passages in Pigs.Ribavirin-resistant variants of foot-and-mouth disease virus: the effect of restricted quasispecies diversity on viral virulence.Arenaviruses and lethal mutagenesis. Prospects for new ribavirin-based interventions.Three-dimensional structure of foot-and-mouth disease virus and its biological functions.Epistatic Interactions within the Influenza A Virus Polymerase Complex Mediate Mutagen Resistance and Replication Fidelity.Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity.Delayed lysis confers resistance to the nucleoside analogue 5-fluorouracil and alleviates mutation accumulation in the single-stranded DNA bacteriophage ϕX174.Lethal mutagenesis of foot-and-mouth disease virus involves shifts in sequence space.Increased replicative fitness can lead to decreased drug sensitivity of hepatitis C virus.Picornaviral polymerase structure, function, and fidelity modulation.Response of hepatitis C virus to long-term passage in the presence of alpha interferon: multiple mutations and a common phenotype.Ribavirin can be mutagenic for arenaviruses.Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.Internal Disequilibria and Phenotypic Diversification during Replication of Hepatitis C Virus in a Noncoevolving Cellular Environment.Barrier-Independent, Fitness-Associated Differences in Sofosbuvir Efficacy against Hepatitis C VirusMultifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.Favipiravir elicits antiviral mutagenesis during virus replication in vivo.Mutagenesis-mediated virus extinction: virus-dependent effect of viral load on sensitivity to lethal defection.Changes in protein domains outside the catalytic site of the bacteriophage Qβ replicase reduce the mutagenic effect of 5-azacytidine.Nucleoside analogue mutagenesis of a single-stranded DNA virus: evolution and resistance.β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome.Foot-and-mouth disease virus type O specific mutations determine RNA-dependent RNA polymerase fidelity and virus attenuation.Emergency Services of Viral RNAs: Repair and Remodeling.
P2860
Q21132564-1F78F004-B01F-48A2-BF78-0F7D5C359228Q26799887-9F0F11CD-FEF8-4B12-AF52-DF44A373D358Q27013917-A864985B-356C-4798-B2E9-348C95BAD33BQ27678100-F5F46434-3CE6-4AA5-9336-3A9EC44D0AE2Q27682030-21FAED5D-49D0-46AA-ABC3-18D3A667E899Q28072953-24619032-9303-4943-A508-0755EA34B0D9Q28535361-5E9E202A-21E5-4788-9736-14CC252BF117Q30394471-E0045046-EAC1-47D0-BC92-F75E21F49E90Q33692707-67F13832-94CB-4EAB-BC13-156B80F636BEQ33704988-F687853F-2281-4767-AC7A-67749C409FE4Q34077949-A5EA2CF2-2C29-4B2B-B301-DAA35CE232A0Q34326649-1B948A6E-9FDC-48E7-9708-1015753619C6Q35058607-E6486228-D7C5-4EEC-BA74-1E98B4AAD825Q35131997-F2F12B05-D911-4241-9F3E-C788F84611D2Q35669158-DFDB2A2E-ADF5-434C-BC9A-0AD80CB1F9EDQ36166222-4C4282AB-2775-422E-92ED-7126A61BE127Q36179597-1B94DB24-71F3-471D-AC26-F90E4184F18FQ36811916-C44247B6-9BFB-49CB-8406-76D58C36394FQ37713899-E30204CE-FC64-4D9E-9E0F-0AF8C92E9A24Q38064285-14FCA68B-6804-41C2-BAA8-93E1BF2266BFQ38265915-4A9D054B-D1B5-41E9-8281-7811EA709431Q38621087-F0FCD145-B8E2-489B-9715-34A555C2F0F2Q38780069-A56E89B0-D81E-4947-B021-941C6E05B919Q38859901-06A742F3-CED0-40E1-A43C-A894DF4BED51Q38961370-98FB300E-45E3-438C-ABD3-4C16752E7E72Q38966123-40DFB4F5-C673-4ABA-AB76-5154218F90EAQ39120524-17F6E95F-6897-4322-804A-E0C186C715BAQ39157496-5EB634AD-BB49-4B17-BE36-B11AA5825F3BQ39544616-E36DF244-938A-44BA-B0DC-5E038278B16DQ39754503-7D20D06B-40D6-4214-B83B-28A03AD7B807Q40301168-3D096F93-C1E0-4AC5-A569-05EC20F4F79AQ40719246-F7C09AAA-3AB3-432D-982A-0F82713B7F52Q41027592-372CAA80-3628-4B61-B3B1-5255E61AF895Q41693281-69A02C69-3BD7-4D63-900C-399C9A9B5CF0Q41896864-1C070B89-5880-4049-AA12-436F881D36F1Q42138232-BB248BCB-B344-4131-94E7-D355430A5B17Q42326356-A5A28C28-10CB-43E7-A2B8-DBFFA5DAF89DQ44170252-5845CD91-A59A-4022-BF3E-D3D1E6C97BFDQ49894251-03DF1866-E723-4083-9928-50D687ACF8DBQ52655516-2D2DD8E3-D476-474B-9961-BA1D88B7E49E
P2860
A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
A Multi-Step Process of Viral ...... pes Leads to Extinction-Escape
@ast
A Multi-Step Process of Viral ...... pes Leads to Extinction-Escape
@en
A Multi-Step Process of Viral ...... pes Leads to Extinction-Escape
@nl
type
label
A Multi-Step Process of Viral ...... pes Leads to Extinction-Escape
@ast
A Multi-Step Process of Viral ...... pes Leads to Extinction-Escape
@en
A Multi-Step Process of Viral ...... pes Leads to Extinction-Escape
@nl
altLabel
A multi-step process of viral ...... pes leads to extinction-escape
@en
prefLabel
A Multi-Step Process of Viral ...... pes Leads to Extinction-Escape
@ast
A Multi-Step Process of Viral ...... pes Leads to Extinction-Escape
@en
A Multi-Step Process of Viral ...... pes Leads to Extinction-Escape
@nl
P2093
P2860
P50
P3181
P1433
P1476
A Multi-Step Process of Viral ...... pes Leads to Extinction-Escape
@en
P2093
Celia Perales
Cristina Ferrer-Orta
Ignacio de la Higuera
Rosa Pérez-Luque
Rubén Agudo
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1001072
P407
P577
2010-08-26T00:00:00Z