The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain - Test2 - elhamkhani - TriplyDB

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

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Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins SHARPIN is an endogenous inhibitor of β1-integrin activation A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins Integrin cytoplasmic tail interactions The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering Membrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin Activation RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1)The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion PIP kinases define PI4,5P₂signaling specificity by association with effectors Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis.Talins and kindlins: partners in integrin-mediated adhesion.New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.The talin dimer structure orientation is mechanically regulated.Membrane-induced structural rearrangement and identification of a novel membrane anchor in talin F2F3 The tail of integrin activation.Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helices The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.Multiscale simulations suggest a mechanism for integrin inside-out activation.The C terminus of talin links integrins to cell cycle progression.Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.Efficient Exploration of Membrane-Associated Phenomena at Atomic Resolution.Subcellular localization of talin is regulated by inter-domain interactions Talin activates integrins by altering the topology of the β transmembrane domain Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation Atomic-level description of protein-lipid interactions using an accelerated membrane model.Myosin MyTH4-FERM structures highlight important principles of convergent evolution.The mechanical response of talin.On the activation of integrin αIIbβ3: outside-in and inside-out pathways.Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation.Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation.Molecular mechanism of inside-out integrin regulation Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering.The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties.Mechanisms of talin-dependent integrin signaling and crosstalk

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The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

http://www.wikidata.org/entity/Q27665036

description

2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

name

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

@ast

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

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The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

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type

label

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

@ast

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

@en

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

@nl

prefLabel

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

@ast

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

@en

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

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J.STR.2010.07.011

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P1476

The Structure of the talin head reveals a novel extended conformation of the FERM domain

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David R Critchley

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Igor L Barsukov

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J Günter Grossmann

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Neil Bate

http://www.w3.org/2001/XMLSchema#string

Paul R Elliott

http://www.w3.org/2001/XMLSchema#string

Petra M Kopp

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P2860

Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides

Structural determinants of integrin recognition by talin

Structural basis of integrin activation by talin

The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling

Determination of domain structure of proteins from X-ray solution scattering

Global rigid body modeling of macromolecular complexes against small-angle scattering data

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

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1289-1299

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4623432

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10.1016/J.STR.2010.07.011

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10

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18

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Benjamin T Goult

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2010-10-01T00:00:00Z

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47428603

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20947018

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structural biology

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2977851

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