A new regulatory switch in a JAK protein kinase

A new regulatory switch in a JAK protein kinase

Item
http://www.wikidata.org/entity/Q27666111
Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibitionTYK2 kinase activity is required for functional type I interferon responses in vivoTargeted kinase selectivity from kinase profiling data.Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells.Therapeutic potential of tyrosine kinase 2 in autoimmunity.Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.Global connectivity of hub residues in Oncoprotein structures encodes genetic factors dictating personalized drug response to targeted Cancer therapy.
P2860

A new regulatory switch in a JAK protein kinase

Item
http://www.wikidata.org/entity/Q27666111
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A new regulatory switch in a JAK protein kinase
@ast
A new regulatory switch in a JAK protein kinase
@en
A new regulatory switch in a JAK protein kinase
@nl
type
label
A new regulatory switch in a JAK protein kinase
@ast
A new regulatory switch in a JAK protein kinase
@en
A new regulatory switch in a JAK protein kinase
@nl
prefLabel
A new regulatory switch in a JAK protein kinase
@ast
A new regulatory switch in a JAK protein kinase
@en
A new regulatory switch in a JAK protein kinase
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
A new regulatory switch in a JAK protein kinase
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698