Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. - Test2 - elhamkhani - TriplyDB

Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways.

Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways.

http://www.wikidata.org/entity/Q36566064

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hTid-1, a human DnaJ protein, modulates the interferon signaling pathway Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD Janus kinases in immune cell signaling JAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase.Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway Mast cell homeostasis and the JAK-STAT pathway Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Bacterial and fungal pattern recognition receptors in homologous innate signaling pathways of insects and mammals PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury A new regulatory switch in a JAK protein kinase The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.JAK/STAT pathway dysregulation in tumors: a Drosophila perspective JNK-induced apoptosis, compensatory growth, and cancer stem cells JAKs, STATs and Src kinases in hematopoiesis.A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling.JAK2 V617F in myeloid disorders: what do we know now, and where are we headed?Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway.Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction.Activation of JAK2-V617F by components of heterodimeric cytokine receptors Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.JAK-STAT signaling activated by Abl oncogenes.IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled.Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains.Janus kinases: components of multiple signaling pathways.Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited.Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells Basement membrane and cell integrity of self-tissues in maintaining Drosophila immunological tolerance The JAK/STAT pathway and Drosophila development.Jak2-Stat5 interactions analyzed in yeast.Regulation of the Jak2 tyrosine kinase by its pseudokinase domain The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction.Identification of Drosophila genes modulating Janus kinase/signal transducer and activator of transcription signal transduction.Regulation of larval hematopoiesis in Drosophila melanogaster: a role for the multi sex combs gene.Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila.The proliferation of Drosophila in cancer research: a system for the functional characterization of tumor suppressors and oncogenes.Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.Recent advances in the bcr-abl negative chronic myeloproliferative diseases.Specific cell ablation in Drosophila using the toxic viral protein M2(H37A).JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.

P2860

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P2860

Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways.

http://www.wikidata.org/entity/Q36566064

description

1997 nî lūn-bûn

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1997年の論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年论文

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1997年论文

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1997年论文

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name

Mutation in the Jak kinase JH2 ...... d mammalian Jak-Stat pathways.

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Mutation in the Jak kinase JH2 ...... d mammalian Jak-Stat pathways.

@en

type

label

Mutation in the Jak kinase JH2 ...... d mammalian Jak-Stat pathways.

@ast

Mutation in the Jak kinase JH2 ...... d mammalian Jak-Stat pathways.

@en

prefLabel

Mutation in the Jak kinase JH2 ...... d mammalian Jak-Stat pathways.

@ast

Mutation in the Jak kinase JH2 ...... d mammalian Jak-Stat pathways.

@en

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Molecular and Cellular Biology

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Mutation in the Jak kinase JH2 ...... d mammalian Jak-Stat pathways.

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C R Dearolf

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D Barber

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H Luo

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P2860

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

Essential role of Stat6 in IL-4 signalling

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

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