about
Selective inhibition of BET bromodomainsHistone recognition and large-scale structural analysis of the human bromodomain familyLarge-scale structural analysis of the classical human protein tyrosine phosphatomeStructural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4Small-molecule inhibition of BRDT for male contraception.Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activationCrystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKsStructural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activityStructural and Functional Characterization of the Human Protein Kinase ASK1Similar Biological Activities of Two Isostructural Ruthenium and Osmium ComplexesExtremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitorsStructure and functional characterization of the atypical human kinase haspinSmall-molecule kinase inhibitors provide insight into Mps1 cell cycle functionNew potent dual inhibitors of CK2 and Pim kinases: discovery and structural insightsThe crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activitySpecific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative SplicingStructurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase InhibitorsIdentification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding ModesBenzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET familyOptimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain LigandsStructures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate RecognitionSmall-Molecule Inhibitors of the c-Fes Protein-Tyrosine KinaseDiscovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual ScreeningRVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomainIdentification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor SpecificityDual kinase-bromodomain inhibitors for rationally designed polypharmacologySelectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine BDiscovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration AnalysisTargeting bromodomains: epigenetic readers of lysine acetylationDiscovery and optimization of small-molecule ligands for the CBP/p300 bromodomainsGeneration of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia TherapySPOTing Acetyl-Lysine Dependent InteractionsMOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.Constitutively active ALK2 receptor mutants require type II receptor cooperation
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Panagis Filippakopoulos
@ast
Panagis Filippakopoulos
@en
Panagis Filippakopoulos
@es
Panagis Filippakopoulos
@fr
Panagis Filippakopoulos
@nl
Panagis Filippakopoulos
@sl
type
label
Panagis Filippakopoulos
@ast
Panagis Filippakopoulos
@en
Panagis Filippakopoulos
@es
Panagis Filippakopoulos
@fr
Panagis Filippakopoulos
@nl
Panagis Filippakopoulos
@sl
prefLabel
Panagis Filippakopoulos
@ast
Panagis Filippakopoulos
@en
Panagis Filippakopoulos
@es
Panagis Filippakopoulos
@fr
Panagis Filippakopoulos
@nl
Panagis Filippakopoulos
@sl
P106
P21
P31
P496
0000-0002-1515-1317
P569
2000-01-01T00:00:00Z