A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers - Test2 - elhamkhani - TriplyDB

A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers

A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers

http://www.wikidata.org/entity/Q27670467

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Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation Immunological cells and functions in Gaucher disease Structural basis of metal hypersensitivity Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy Peptide length determines the outcome of TCR/peptide-MHCI engagement A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex Lack of heterologous cross-reactivity towards HLA-A*02:01 restricted viral epitopes is underpinned by distinct αβT cell receptor signatures αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection T cells and their eons-old obsession with MHC Memory NK cells: why do they reside in the liver?Specific increase in potency via structure-based design of a TCR.Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function Evolutionarily conserved features contribute to αβ T cell receptor specificity Identification of a naturally processed HLA-Cw7-binding peptide that cross-reacts with HLA-A24-restricted ovarian cancer-specific CTLs.Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.Cumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicity Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.The T-cell receptor is not hardwired to engage MHC ligands.Recognition of self and altered self by T cells in autoimmunity and allergy.TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition.Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes.Advances in direct T-cell alloreactivity: function, avidity, biophysics and structure.How the TCR balances sensitivity and specificity for the recognition of self and pathogens.Structural and dynamic control of T-cell receptor specificity, cross-reactivity, and binding mechanism.A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned.Understanding the complexity and malleability of T-cell recognition.Clinical Role of Human Leukocyte Antigen in Health and Disease.Conserved Vδ1 binding geometry in a setting of locus-disparate pHLA recognition by δ/αβTCRs: insight into recognition of HIV peptides by TCR.SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells.A study of CDR3 loop dynamics reveals distinct mechanisms of peptide recognition by T-cell receptors exhibiting different levels of cross-reactivity.Sex bias in MHC I-associated shaping of the adaptive immune system.Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts.Mycobacterium tuberculosis peptide E7/HLA-DRB1 tetramers with different HLA-DR alleles bound CD4+ T cells might share identical CDR3 region.

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A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers

http://www.wikidata.org/entity/Q27670467

description

2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

A Single T Cell Receptor Bound ...... eals Switchable TCR Conformers

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A Single T Cell Receptor Bound ...... eals Switchable TCR Conformers

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A Single T Cell Receptor Bound ...... eals Switchable TCR Conformers

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label

A Single T Cell Receptor Bound ...... eals Switchable TCR Conformers

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A Single T Cell Receptor Bound ...... eals Switchable TCR Conformers

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A Single T Cell Receptor Bound ...... eals Switchable TCR Conformers

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prefLabel

A Single T Cell Receptor Bound ...... eals Switchable TCR Conformers

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A Single T Cell Receptor Bound ...... eals Switchable TCR Conformers

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A Single T Cell Receptor Bound ...... eals Switchable TCR Conformers

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J.IMMUNI.2011.04.017

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A Single T Cell Receptor Bound ...... eals Switchable TCR Conformers

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Clamencia Pinilla

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Eric Huseby

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Frances Crawford

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Shaodong Dai

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P2860

Crystal structure of a T cell receptor bound to an allogeneic MHC molecule

A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex

The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?

How a single T cell receptor recognizes both self and foreign MHC

Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'

Single MHC Mutation Eliminates Enthalpy Associated with T Cell Receptor Binding

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Philippa Marrack

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51229119

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