Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
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Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptorMembrane potentials regulating GPCRs: insights from experiments and molecular dynamics simulationsThe Use of Multiscale Molecular Simulations in Understanding a Relationship between the Structure and Function of Biological Systems of the Brain: The Application to Monoamine Oxidase EnzymesLarge-scale production and protein engineering of G protein-coupled receptors for structural studiesPrinciples of allosteric interactions in cell signalingMolecular switches of the κ opioid receptor triggered by 6'-GNTI and 5'-GNTI.Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments.Preferred supramolecular organization and dimer interfaces of opioid receptors from simulated self-associationStructural basis for bifunctional peptide recognition at human δ-opioid receptorMolecular control of δ-opioid receptor signallingLipidic cubic phase injector facilitates membrane protein serial femtosecond crystallographyThe 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free ReceptorMembrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR FunctionStructural basis of Smoothened regulation by its extracellular domainsLipid receptor S1P₁ activation scheme concluded from microsecond all-atom molecular dynamics simulationsAge-related differences in bitter taste and efficacy of bitter blockersStructural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist bindingThe Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine DerivativesRole of Annular Lipids in the Functional Properties of Leucine Transporter LeuT ProteomicellesHow genetic errors in GPCRs affect their function: Possible therapeutic strategiesSequence, structure and ligand binding evolution of rhodopsin-like G protein-coupled receptors: a crystal structure-based phylogenetic analysisIn search of novel ligands using a structure-based approach: a case study on the adenosine A2A receptorCholesterol binding to ion channelsAdenosine receptors as drug targets--what are the challenges?A two-state model for the diffusion of the A2A adenosine receptor in hippocampal neurons: agonist-induced switch to slow mobility is modified by synapse-associated protein 102 (SAP102)Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization.Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory.The role of experimental and computational structural approaches in 7TM drug discovery.The power of mass spectrometry in structural characterization of GPCR signaling.Structure and function of serotonin G protein-coupled receptors.NMR of Membrane Proteins: Beyond Crystals.Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergentMechanism of allosteric regulation of β2-adrenergic receptor by cholesterol.Fast iodide-SAD phasing for high-throughput membrane protein structure determinationSeven perspectives on GPCR H/D-exchange proteomics methodsThe second extracellular loop of the adenosine A1 receptor mediates activity of allosteric enhancersCompound activity prediction using models of binding pockets or ligand properties in 3D.Structure-function of the G protein-coupled receptor superfamily.Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.
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P2860
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
@ast
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
@en
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
@nl
type
label
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
@ast
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
@en
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
@nl
prefLabel
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
@ast
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
@en
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
@nl
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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
@en
P2093
Aaron A Thompson
Christopher B Roth
Eugene Chun
Gye Won Han
Pavel Chubukov
Raymond C Stevens
P2860
P3181
P356
10.1126/SCIENCE.1219218
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P577
2012-07-13T00:00:00Z