Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels
about
Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activationNovel phenolic inhibitors of small/intermediate-conductance Ca²⁺-activated K⁺ channels, KCa3.1 and KCa2.3Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1)The activation effect of hainantoxin-I, a peptide toxin from the Chinese spider, Ornithoctonus hainana, on intermediate-conductance Ca2+-activated K+ channels.New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo.Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin InterfaceSelective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complexProtein-protein interactions as drug targets.Molecular overlap in the regulation of SK channels by small molecules and phosphoinositidesIncreased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress.Calcium-dependent stoichiometries of the KCa2.2 (SK) intracellular domain/calmodulin complex in solution.Structural diversity of calmodulin binding to its target sites.International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels.Contribution of the KCa3.1 channel-calmodulin interactions to the regulation of the KCa3.1 gating process.Are there superagonists for calcium-activated potassium channels?Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121).Structural insights into the potency of SK channel positive modulators.Stabilization of protein-protein interactions in drug discovery.Pharmacologic targeting of endothelial Ca2+-activated K+ channels: A strategy to improve cardiovascular function.A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model.
P2860
Q27676817-B5886FC1-420C-4172-975C-59549BC1FA47Q28488052-86BBC50B-6E3C-45BF-A16B-E93BDB250417Q28833834-14E64012-C846-44CC-86BE-4509474B49D9Q34101834-A5940219-5659-4F28-9149-2EBF7A1E4DFEQ34125233-E0873847-7051-4247-8A95-0C360522A656Q34946861-C91A7FF4-0256-4218-82A5-FFCCF600CB67Q35329866-1BBCC352-9EEF-4C66-8051-23BED2225760Q35570980-2F4674DE-DA72-4864-96E3-C0EDC97920CBQ35824701-067C131E-D157-43F4-98CB-5D1F7D145E59Q36040703-0D60C957-5386-4850-9951-7CD9409F7FE7Q36064165-29CB093F-FD8D-4111-8062-1461FB431183Q37727037-B8F8A45F-EF6D-4E88-8C4F-487EDA74499DQ38100292-A4F62F62-93F4-4D58-B824-1997460C2AB6Q39166252-E14CDB92-C0A7-49CC-8B2D-B3C72AE4DB18Q41866976-AD9395B9-90D2-424D-949B-4FFCBF85C1C7Q46119791-751039D8-2A0C-4442-83AF-C04EC55030E5Q46315519-4676E374-A018-41B2-A07F-FE93C4C518BDQ46403133-55DC017F-85F3-4B9E-B46F-42A5AA030B23Q47938743-03E791BE-E354-4F75-9C8C-581B8A6E1705Q52631909-A074100D-C599-4344-9538-4344FC4D707DQ55714938-89053EAC-86C9-4EEA-A214-9F3A4333ABBB
P2860
Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Identification of the function ...... +-activated potassium channels
@ast
Identification of the function ...... +-activated potassium channels
@en
Identification of the function ...... +-activated potassium channels
@nl
type
label
Identification of the function ...... +-activated potassium channels
@ast
Identification of the function ...... +-activated potassium channels
@en
Identification of the function ...... +-activated potassium channels
@nl
prefLabel
Identification of the function ...... +-activated potassium channels
@ast
Identification of the function ...... +-activated potassium channels
@en
Identification of the function ...... +-activated potassium channels
@nl
P2093
P2860
P356
P1476
Identification of the function ...... +-activated potassium channels
@en
P2093
Ji-Fang Zhang
John M Pascal
Miao Zhang
Roger S Armen
P2860
P2888
P356
10.1038/NCOMMS2017
P407
P577
2012-01-01T00:00:00Z
P5875
P6179
1049947780