A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme
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Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionPostsynaptic signaling during plasticity of dendritic spinesL-type calcium channel targeting and local signalling in cardiac myocytesMechanisms of CaMKII action in long-term potentiationCalmodulin-dependent protein kinase II: linking heart failure and arrhythmiasMechanisms of altered Ca²⁺ handling in heart failureNew therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII)An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 PseudokinaseStructural basis for the inhibition of Polo-like kinase 1Calmodulin regulation of TMEM16A and 16B Ca(2+)-activated chloride channelsCaMKII binding to GluN2B is critical during memory consolidationPLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIαFast Decay of CaMKII FRET Sensor Signal in Spines after LTP Induction Is Not Due to Its Dephosphorylation.Calcium-calmodulin-dependent protein kinase II isoforms differentially impact the dynamics and structure of the actin cytoskeletonThe CaMKII holoenzyme structure in activation-competent conformationsHigh-throughput SAXS for the characterization of biomolecules in solution: a practical approachNitric oxide induces Ca2+-independent activity of the Ca2+/calmodulin-dependent protein kinase II (CaMKII).Three ways to die suddenly: do they all require calcium calmodulin-dependent protein kinase II?A significant but rather mild contribution of T286 autophosphorylation to Ca2+/CaM-stimulated CaMKII activity.CaMKII activation and dynamics are independent of the holoenzyme structure: an infinite subunit holoenzyme approximationFluorescence polarization and fluctuation analysis monitors subunit proximity, stoichiometry, and protein complex hydrodynamicsBio-inspired voltage-dependent calcium channel blockersCaMKII binding to GluN2B is differentially affected by macromolecular crowding reagents.Development of a molecularly evolved, highly sensitive CaMKII FRET sensor with improved expression pattern.Covert Changes in CaMKII Holoenzyme Structure Identified for Activation and Subsequent Interactions.Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cellsMethionine Mistranslation Bypasses the Restraint of the Genetic Code to Generate Mutant Proteins with Distinct Activities.Live imaging of endogenous Ca²⁺/calmodulin-dependent protein kinase II in neurons reveals that ischemia-related aggregation does not require kinase activityCaMKII regulation in information processing and storage.Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoformPhosphorylation at Ser²⁶ in the ATP-binding site of Ca²⁺/calmodulin-dependent kinase II as a mechanism for switching off the kinase activity.Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase IIDeath-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct SitesStructural basis of Dscam1 homodimerization: Insights into context constraint for protein recognitionThe delicate bistability of CaMKIIPhosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIα Regulation Inversely Induced by Cocaine Memory Extinction versus ReconsolidationMultiple CaMKII Binding Modes to the Actin Cytoskeleton Revealed by Single-Molecule Imaging.Identifying protein kinase target preferences using mass spectrometry.Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase IIApo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain.
P2860
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P2860
A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A Mechanism for Tunable Autoin ...... Dependent Kinase II Holoenzyme
@ast
A Mechanism for Tunable Autoin ...... Dependent Kinase II Holoenzyme
@en
A Mechanism for Tunable Autoin ...... Dependent Kinase II Holoenzyme
@nl
type
label
A Mechanism for Tunable Autoin ...... Dependent Kinase II Holoenzyme
@ast
A Mechanism for Tunable Autoin ...... Dependent Kinase II Holoenzyme
@en
A Mechanism for Tunable Autoin ...... Dependent Kinase II Holoenzyme
@nl
altLabel
A mechanism for tunable autoin ...... dependent kinase II holoenzyme
@en
prefLabel
A Mechanism for Tunable Autoin ...... Dependent Kinase II Holoenzyme
@ast
A Mechanism for Tunable Autoin ...... Dependent Kinase II Holoenzyme
@en
A Mechanism for Tunable Autoin ...... Dependent Kinase II Holoenzyme
@nl
P2093
P2860
P50
P921
P3181
P1433
P1476
A Mechanism for Tunable Autoin ...... Dependent Kinase II Holoenzyme
@en
P2093
Daniel J Mandell
Howard Schulman
Il-Hyung Lee
Jay T Groves
Joshua Levitz
Margaret M Stratton
Oren S Rosenberg
P2860
P304
P3181
P356
10.1016/J.CELL.2011.07.038
P407
P577
2011-09-02T00:00:00Z