Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection
about
DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosisDJ-1 is a copper chaperone acting on SOD1 activationRole of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses.Network analysis reveals common host protein/s modulating pathogenesis of neurotropic virusesMorphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathwayBehavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models.Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.Comparative proteome analysis of brown adipose tissue in obese C57BL/6J mice using iTRAQ-coupled 2D LC-MS/MSDJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating Pink1.Absence of the Yeast Hsp31 Chaperones of the DJ-1 Superfamily Perturbs Cytoplasmic Protein Quality Control in Late Growth Phase.Interaction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis.Oxidative stress mechanisms underlying Parkinson's disease-associated neurodegeneration in C. elegans.Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism.Protective and toxic roles of dopamine in Parkinson's disease.Role of autophagy and its significance in cellular homeostasis.Autophagy in neuronal cells: general principles and physiological and pathological functions.Cysteine-mediated redox signalling in the mitochondria.Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.Parkin, PINK1 and DJ1 as possible modulators of mTOR pathway in ganglioglioma.Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?Parkin modulates expression of HIF-1α and HIF-3α during hypoxia in gliobastoma-derived cell lines in vitro.Mitochondrial quality control by the Pink1/Parkin system.Parkin and mitophagy in cancer.Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes.Neurodegeneration in ataxia-telangiectasia: Multiple roles of ATM kinase in cellular homeostasis.Protective effects of fisetin and other berry flavonoids in Parkinson's disease.Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy.Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.Molecular dynamics simulations of human E3 ubiquitin ligase Parkin.The cell and molecular biology of neurodegenerative diseases: an overview.Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment.An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1.Analysis of blood-based gene expression in idiopathic Parkinson disease.Current therapeutic molecules and targets in neurodegenerative diseases based on in silico drug design.PINK1 autophosphorylation is required for ubiquitin recognition.The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?
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P2860
Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection
description
2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
@zh-mo
2013年論文
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2013年论文
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name
Structure and Function of Park ...... Musketeers of Neuroprotection
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Structure and Function of Park ...... Musketeers of Neuroprotection
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Structure and Function of Park ...... Musketeers of Neuroprotection
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Structure and Function of Park ...... Musketeers of Neuroprotection
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type
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Structure and Function of Park ...... Musketeers of Neuroprotection
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Structure and Function of Park ...... Musketeers of Neuroprotection
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Structure and Function of Park ...... Musketeers of Neuroprotection
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Structure and Function of Park ...... Musketeers of Neuroprotection
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Structure and Function of Park ...... Musketeers of Neuroprotection
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Structure and Function of Park ...... Musketeers of Neuroprotection
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Structure and Function of Park ...... Musketeers of Neuroprotection
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Structure and Function of Park ...... Musketeers of Neuroprotection
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P2860
P3181
P356
P1476
Structure and Function of Park ...... Musketeers of Neuroprotection
@en
P2093
Jean-François Trempe
P2860
P3181
P356
10.3389/FNEUR.2013.00038
P407
P577
2013-01-01T00:00:00Z