Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation - Test2 - elhamkhani - TriplyDB

Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

http://www.wikidata.org/entity/Q27672864

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The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations Chemical methods for decoding cytosine modifications in DNA Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH DNA Recognition of 5-Carboxylcytosine by a Zfp57 Mutant at an Atomic Resolution of 0.97 Å Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA Merging data from genetic and epigenetic approaches to better understand autistic spectrum disorder.A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation.A Chemical Probe Targets DNA 5-Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression.Epigenetic regulation of asthma and allergic disease.Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines.Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution.The theory of RNA-mediated gene evolution Effects of Tet-mediated oxidation products of 5-methylcytosine on DNA transcription in vitro and in mammalian cells.The carboxy-terminal domain of ROS1 is essential for 5-methylcytosine DNA glycosylase activity Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription.Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging.Accurate measurement of 5-methylcytosine and 5-hydroxymethylcytosine in human cerebellum DNA by oxidative bisulfite on an array (OxBS-array).Base excision repair in physiology and pathology of the central nervous system Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance.Weakened N3 Hydrogen Bonding by 5-Formylcytosine and 5-Carboxylcytosine Reduces Their Base-Pairing Stability Selective excision of 5-carboxylcytosine by a thymine DNA glycosylase mutant.Characterizing DNA methylation alterations from The Cancer Genome Atlas.Characterization of TET and IDH gene expression in chronic lymphocytic leukemia: comparison with normal B cells and prognostic significance Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA.A current view of the epigenome in mouse primordial germ cells.DNA methylation and demethylation: a pathway to gametogenesis and development.5-hydroxymethylcytosine profiling as an indicator of cellular state.Role of DNA methylation and the DNA methyltransferases in learning and memory.Biological and biochemical modulation of DNA methylation.Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics.DNA modifications in models of alcohol use disorders.Structural and mutation studies of two DNA demethylation related glycosylases: MBD4 and TDG.Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNA

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Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation

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2012 nî lūn-bûn

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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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Excision of 5-hydroxymethylura ...... s for active DNA demethylation

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Excision of 5-hydroxymethylura ...... s for active DNA demethylation

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Excision of 5-hydroxymethylura ...... s for active DNA demethylation

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Excision of 5-hydroxymethylura ...... s for active DNA demethylation

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Excision of 5-hydroxymethylura ...... s for active DNA demethylation

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Excision of 5-hydroxymethylura ...... s for active DNA demethylation

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Excision of 5-hydroxymethylura ...... s for active DNA demethylation

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Excision of 5-hydroxymethylura ...... s for active DNA demethylation

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Excision of 5-hydroxymethylura ...... s for active DNA demethylation

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Nucleic Acids Research

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Excision of 5-hydroxymethylura ...... s for active DNA demethylation

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Ashok S Bhagwat

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Hideharu Hashimoto

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Samuel Hong

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Xiaodong Cheng

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Xing Zhang

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P2860

Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA

Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites

Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover

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3797309

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10.1093/NAR/GKS845

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20

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40

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2012-11-01T00:00:00Z

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230827074

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22962365

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3488261

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