Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
about
Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylaseThymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNALesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNAThymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sitesA decade of exploring the cancer epigenome - biological and translational implicationsTet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosineDNA demethylation dynamicsTet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNAAcute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identityGut Microbiota Imbalance and Base Excision Repair Dynamics in Colon CancerThe current state of eukaryotic DNA base damage and repairEnabling functional genomics with genome engineeringEpigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyondRepair of oxidative DNA damage and cancer: recent progress in DNA base excision repairMechanisms and functions of Tet protein-mediated 5-methylcytosine oxidationEpigenetic control on cell fate choice in neural stem cellsActive DNA demethylation in post-mitotic neurons: a reason for optimismReprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriersDNA glycosylases: in DNA repair and beyondNuclear receptors and epigenetic regulation: opportunities for nutritional targeting and disease preventionDNA methylation in mammals5-Hydroxymethylcytosine: A new player in brain disorders?Connections between TET proteins and aberrant DNA modification in cancerThe roles of retinoic acid and retinoic acid receptors in inducing epigenetic changesMBD2 and MBD3: elusive functions and mechanismsMechanism and function of oxidative reversal of DNA and RNA methylationDNA demethylation and invasive cancer: implications for therapeuticsStructure and function of dioxygenases in histone demethylation and DNA/RNA demethylationRole of epigenetic aberrations in the development and progression of human hepatocellular carcinomaRole of mecp2 in experience-dependent epigenetic programmingEtoposide induces nuclear re-localisation of AIDDose dependent effects on cell cycle checkpoints and DNA repair by bendamustineExcision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylationBiochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNAExcision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylationStructural Basis of the Versatile DNA Recognition Ability of the Methyl-CpG Binding Domain of Methyl-CpG Binding Domain Protein 4Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pHMetal-Dependent Conformational Activation Explains Highly Promutagenic Replication across O6-Methylguanine by Human DNA Polymerase βStructural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residuesRole of TET enzymes in DNA methylation, development, and cancer
P2860
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P2860
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Thymine DNA glycosylase is ess ...... amination-base excision repair
@ast
Thymine DNA glycosylase is ess ...... amination-base excision repair
@en
Thymine DNA glycosylase is ess ...... amination-base excision repair
@en-gb
Thymine DNA glycosylase is ess ...... amination-base excision repair
@nl
type
label
Thymine DNA glycosylase is ess ...... amination-base excision repair
@ast
Thymine DNA glycosylase is ess ...... amination-base excision repair
@en
Thymine DNA glycosylase is ess ...... amination-base excision repair
@en-gb
Thymine DNA glycosylase is ess ...... amination-base excision repair
@nl
prefLabel
Thymine DNA glycosylase is ess ...... amination-base excision repair
@ast
Thymine DNA glycosylase is ess ...... amination-base excision repair
@en
Thymine DNA glycosylase is ess ...... amination-base excision repair
@en-gb
Thymine DNA glycosylase is ess ...... amination-base excision repair
@nl
P2093
P2860
P3181
P1433
P1476
Thymine DNA glycosylase is ess ...... amination-base excision repair
@en
P2093
Alfonso Bellacosa
Andres J Klein-Szanto
Andy Wessels
Antonio Cigliano
Catherine Renner
Christophe Alberti
Dianne Soprano
Dominique Kobi
Elena Caretti
Florian Rambow
P2860
P3181
P356
10.1016/J.CELL.2011.06.020
P407
P577
2011-07-08T00:00:00Z