Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
about
Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus TherapyCurrent and potential treatments for ubiquitous but neglected herpesvirus infectionsOrdering a Dynamic Protein Via a Small-Molecule StabilizerCrystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding PocketSubstrate Deconstruction and the Nonadditivity of Enzyme RecognitionStructure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDOStructural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172High-throughput screening (HTS) and hit validation to identify small molecule inhibitors with activity against NS3/4A proteases from multiple hepatitis C virus genotypesTowards structural systems pharmacology to study complex diseases and personalized medicineEmerging Computational Methods for the Rational Discovery of Allosteric Drugs.Statistical linkage analysis of substitutions in patient-derived sequences of genotype 1a hepatitis C virus nonstructural protein 3 exposes targets for immunogen designDetection of secondary binding sites in proteins using fragment screeningNatural HCV variants with increased replicative fitness due to NS3 helicase mutations in the C-terminal helix α18The linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus.Computational study on the inhibitor binding mode and allosteric regulation mechanism in hepatitis C virus NS3/4A proteinThe hypervariable amino-terminus of P1 protease modulates potyviral replication and host defense responses.Discovering new medicines targeting helicases: challenges and recent progress.Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery.Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric ProteaseEvaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.Identification and biochemical characterization of halisulfate 3 and suvanine as novel inhibitors of hepatitis C virus NS3 helicase from a marine sponge.Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life Cycle.Uncoupling of Protease trans-Cleavage and Helicase Activities in Pestivirus NS3.Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities.NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA.Using tert-Butyl Groups in a Ligand To Identify Its Binding Site on a Protein.Co-evolution networks of HIV/HCV are modular with direct association to structure and function
P2860
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P2860
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
@ast
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
@en
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
@nl
type
label
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
@ast
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
@en
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
@nl
prefLabel
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
@ast
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
@en
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
@nl
P2093
P2860
P3181
P356
P1476
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
@en
P2093
Andrew J Woodhead
Brent Graham
Caroline J Richardson
Harren Jhoti
Joseph Coyle
Maria G Carr
Pamela A Williams
Puja Pathuri
Sharna J Rich
Steven D Hiscock
P2860
P2888
P304
P3181
P356
10.1038/NCHEMBIO.1081
P577
2012-09-30T00:00:00Z
P5875
P6179
1037343584