Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease

Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease

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http://www.wikidata.org/entity/Q27675348
Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactamsTargeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's diseaseN- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.Pharmacological chaperone design for reducing risk factor of Parkinson's disease from traditional chinese medicine.Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases.New Directions in Gaucher Disease.Bicyclic derivatives of L-idonojirimycin as pharmacological chaperones for neuronopathic forms of Gaucher disease.Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases.Ambroxol as a pharmacological chaperone for mutant glucocerebrosidase.Structure-Activity Studies of N-Butyl-1-deoxynojirimycin (NB-DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2.Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier.Conformational regulation of substituted azepanes through selective monofluorination.
P2860

Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease

Item
http://www.wikidata.org/entity/Q27675348
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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Binding of 3,4,5,6-Tetrahydrox ...... one Design for Gaucher Disease
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Binding of 3,4,5,6-Tetrahydrox ...... one Design for Gaucher Disease
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Binding of 3,4,5,6-Tetrahydrox ...... one Design for Gaucher Disease
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Binding of 3,4,5,6-Tetrahydrox ...... one Design for Gaucher Disease
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Binding of 3,4,5,6-Tetrahydrox ...... one Design for Gaucher Disease
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Binding of 3,4,5,6-Tetrahydrox ...... one Design for Gaucher Disease
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Binding of 3,4,5,6-Tetrahydrox ...... one Design for Gaucher Disease
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Binding of 3,4,5,6-Tetrahydrox ...... one Design for Gaucher Disease
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Binding of 3,4,5,6-tetrahydrox ...... one design for Gaucher disease
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P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932