Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease
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Emerging preclinical pharmacological targets for Parkinson's diseaseOsteoporosis and alzheimer pathology: Role of cellular stress response and hormetic redox signaling in aging and bone remodelingAlpha-synuclein biology in Lewy body diseasesIdentification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for TauopathiesA natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicityA relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synucleinBinding cavities and druggability of intrinsically disordered proteins.Structure-Based Small Molecule Modulation of a Pre-Amyloid State: Pharmacological Enhancement of IAPP Membrane-Binding and Toxicity.Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in CellsDiscovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1).Targeting intrinsically disordered proteins in rational drug discovery.Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc.Finding Our Way in the Dark Proteome.Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.Combating neurodegenerative disease with chemical probes and model systems.The ongoing pursuit of neuroprotective therapies in Parkinson disease.Targeting α-synuclein as a therapeutic strategy for Parkinson's disease.Review: Parkinson's disease: from synaptic loss to connectome dysfunction.Methods of probing the interactions between small molecules and disordered proteins.Amphiphilic copolymers reduce aggregation of unfolded lysozyme more effectively than polyethylene glycol.An update on potential therapeutic strategies for Parkinson's disease based on pathogenic mechanisms.An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules.Foldamer-mediated manipulation of a pre-amyloid toxinNon-covalent S···O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation.Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease.iPS cells in the study of PD molecular pathogenesis.Alpha-synuclein, proteotoxicity and Parkinson's disease: Search for neuroprotective therapy.Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy.A Small Molecule Causes a Population Shift in the Conformational Landscape of an Intrinsically Disordered Protein.Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.Ramachandran mapping of peptide conformation using a large database of computed Raman and Raman optical activity spectra.Role of the microtubule-associated TPPP/p25 in Parkinson's and related diseases and its therapeutic potential.A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.
P2860
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P2860
Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease
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2014 nî lūn-bûn
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2014 թուականին հրատարակուած գիտական յօդուած
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2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
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name
Targeting the intrinsically di ...... rategy for Parkinson's disease
@ast
Targeting the intrinsically di ...... rategy for Parkinson's disease
@en
Targeting the intrinsically di ...... rategy for Parkinson's disease
@nl
type
label
Targeting the intrinsically di ...... rategy for Parkinson's disease
@ast
Targeting the intrinsically di ...... rategy for Parkinson's disease
@en
Targeting the intrinsically di ...... rategy for Parkinson's disease
@nl
prefLabel
Targeting the intrinsically di ...... rategy for Parkinson's disease
@ast
Targeting the intrinsically di ...... rategy for Parkinson's disease
@en
Targeting the intrinsically di ...... rategy for Parkinson's disease
@nl
P2093
P2860
P50
P3181
P1433
P1476
Targeting the intrinsically di ...... rategy for Parkinson's disease
@en
P2093
Carlos W Bertoncini
Dale Schenk
Gaia Skibinski
Gergely Tóth
Jean-Christophe Rochet
John Christodoulou
John P Anderson
Kari Callaway
Karin Regnstrom
Lisa McConlogue
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0087133
P407
P50
P577
2014-01-01T00:00:00Z