Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation
about
Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavageTy3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetryCoordination between the polymerase and RNase H activity of HIV-1 reverse transcriptaseBiophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.Anti-HIV drug development through computational methods.Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors.Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.Convergent evolution of ribonuclease h in LTR retrotransposons and retroviruses.The nature of the N-terminal amino acid residue of HIV-1 RNase H is critical for the stability of reverse transcriptase in viral particles.Retroviral DNA Transposition: Themes and VariationsSiRNA-induced mutation in HIV-1 polypurine tract region and its influence on viral fitness.Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors.Free Energy-Based Virtual Screening and Optimization of RNase H Inhibitors of HIV-1 Reverse Transcriptase.Structure of the HIV-1 reverse transcriptase Q151M mutant: insights into the inhibitor resistance of HIV-1 reverse transcriptase and the structure of the nucleotide-binding pocket of Hepatitis B virus polymerase.Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity.Examining the role of the HIV-1 reverse transcriptase p51 subunit in positioning and hydrolysis of RNA/DNA hybridsConformational Plasticity of the NNRTI-Binding Pocket in HIV-1 Reverse Transcriptase: A Fluorine Nuclear Magnetic Resonance Study.Efavirenz stimulates HIV-1 reverse transcriptase RNase H activity by a mechanism involving increased substrate binding and secondary cleavage activity.Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.Reverse Transcription in the Saccharomyces cerevisiae Long-Terminal Repeat Retrotransposon Ty3.Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase.NMR structure of the HIV-1 reverse transcriptase thumb subdomain.HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently.A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs.Purification and enzymatic characterization of the hepatitis B virus ribonuclease H, a new target for antiviral inhibitors.Arm-specific cleavage and mutation during reverse transcription of 2΄,5΄-branched RNA by Moloney murine leukemia virus reverse transcriptaseQuantitative Resolution of Monomer-Dimer Populations by Inversion Modulated DEER EPR Spectroscopy.Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis.Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a β-thujaplicinol analogue.Reply to "Structural requirements for RNA degradation by HIV-1 reverse transcriptase".Fingerprints of Modified RNA Bases from Deep Sequencing Profiles.RNase H sequence preferences influence antisense oligonucleotide efficiency.Novel insights from structural analysis of lentiviral and gammaretroviral reverse transcriptases in complex with RNA/DNA hybrids.RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview.Probing Conformational States of the Finger and Thumb Subdomains of HIV-1 Reverse Transcriptase Using Double Electron-Electron Resonance Electron Paramagnetic Resonance Spectroscopy.Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase.Transcriptional inaccuracy threshold attenuates differences in RNA-dependent DNA synthesis fidelity between retroviral reverse transcriptases.Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid.Specific reverse transcriptase slippage at the HIV ribosomal frameshift sequence: potential implications for modulation of GagPol synthesis.
P2860
Q27684014-D3EA3CB5-5E8C-4840-B4AE-9BBE337A3C5DQ27689454-8425FB66-1F81-4F9D-81CC-3D7285AC09A5Q33557531-458F7ACB-7BD4-4CD2-9336-E30C0DE093EEQ33649797-C6928368-7A35-4A5E-8A27-BD38CB7C1CA2Q33803979-ED891C22-FC67-4021-9E4F-465167941B74Q34303603-99F65D24-9B82-4F7A-8D70-8344981294F2Q34372481-5119D928-2639-4671-98E5-9AB6F60485B0Q34458880-B652E27D-0119-45A0-8FDC-1788EC302549Q34991047-9BF0070A-DAFB-4AB9-B5D2-131F78C597B0Q35249277-B650F868-8E1F-4330-91DD-9C8DA17776AFQ35362902-B5FF4D36-1D63-4FAF-8101-ADAFB610D99EQ35962212-B7F3F1E1-8C41-4774-9C4A-B5786EF7E7C2Q36155983-9EB2159E-95A7-404A-AE01-459A9D5F9364Q36244591-98045D34-173E-4E24-8F27-FC995D8ADA89Q36250808-8966F322-2138-475C-A830-4BC17E29AA0DQ36890771-D26626E5-6BB8-4A60-8F8D-8D77151374D7Q37114525-3A51F196-3AAB-49EB-A001-FE772369113BQ37350895-854C6AF7-0000-46C7-AB3E-94BB5498A8C1Q37432679-7239C6ED-502C-407D-B463-204679E2E584Q37727825-765B7A4A-BF1E-4C93-86E1-5150753FAC72Q38164838-70837ED2-279C-416D-B565-DC7A6CCA09E0Q39178488-B89B9F3A-2034-49CE-B76E-FA0F4732DEB3Q39253058-F92168C9-EC02-4C83-B440-F2602E1170C3Q39627553-C5D72F8C-3A16-47BE-81D4-AE2636194E8DQ39671295-AB5A2ECA-E095-4B82-BE22-7680BA4DD58CQ40350043-F33CD15C-C21D-4579-9223-F65E1BD76B3BQ41504747-B45FBEBF-C507-4915-A98C-1230B8D1FB10Q42170864-65DFA4ED-A5A9-4A17-B147-690D87E62293Q42190198-FF64E213-388C-4B56-8728-D76FA86D305DQ42251889-2A72B4C4-DFBE-4D9A-AD59-2F5BD5726734Q42958438-F1CBA794-A8C9-4A3A-884C-ED848E81ED6BQ46801206-85CB8966-C020-4861-9E18-BEB90392D0E0Q47105131-8B5DF771-A6F6-4589-9560-B69F474B0450Q47128967-5D04E679-747E-4A4F-85FA-3EB6C29DE5B2Q47235409-18EC3B22-F425-4768-8179-BF7B7BFCF92BQ47292362-ECE19439-0FA7-4A0B-AF53-848EA9E83B8FQ47364014-15108E41-8052-4E5C-A570-48A695A882F4Q47554138-57E03FF3-28F6-400B-980E-0204993DC101Q47558759-F9B0C445-1D18-42FE-B7D7-9126B1E7DC33Q47624537-8C6B4586-68D5-4DC3-B1C7-906A7C6D0120
P2860
Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Complexes of HIV-1 RT, NNRTI a ...... ompatible with RNA degradation
@ast
Complexes of HIV-1 RT, NNRTI a ...... ompatible with RNA degradation
@en
Complexes of HIV-1 RT, NNRTI a ...... ompatible with RNA degradation
@nl
type
label
Complexes of HIV-1 RT, NNRTI a ...... ompatible with RNA degradation
@ast
Complexes of HIV-1 RT, NNRTI a ...... ompatible with RNA degradation
@en
Complexes of HIV-1 RT, NNRTI a ...... ompatible with RNA degradation
@nl
prefLabel
Complexes of HIV-1 RT, NNRTI a ...... ompatible with RNA degradation
@ast
Complexes of HIV-1 RT, NNRTI a ...... ompatible with RNA degradation
@en
Complexes of HIV-1 RT, NNRTI a ...... ompatible with RNA degradation
@nl
P2093
P2860
P3181
P356
P1476
Complexes of HIV-1 RT, NNRTI a ...... ompatible with RNA degradation
@en
P2093
Jennifer T Miller
Mikalai Lapkouski
Stuart F J Le Grice
P2860
P2888
P3181
P356
10.1038/NSMB.2485
P577
2013-02-01T00:00:00Z
P5875
P6179
1040101392