Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain - Test2 - elhamkhani - TriplyDB

Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain

Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain

http://www.wikidata.org/entity/Q27676675

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Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1 Double strand break repair functions of histone H2AX BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response.Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin.NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint Dimerization Mediated by a Divergent Forkhead-associated Domain Is Essential for the DNA Damage and Spindle Functions of Fission Yeast Mdb1.INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells.Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activation Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks.DNA damage sensing by the ATM and ATR kinases.DNA Damage Response-Independent Role for MDC1 in Maintaining Genomic Stability Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis.Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ATM phosphorylates MDC1 Phenotypic Analysis of ATM Protein Kinase in DNA Double-Strand Break Formation and Repair.

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P2860

Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain

http://www.wikidata.org/entity/Q27676675

description

2012 nî lūn-bûn

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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2012 թվականի մայիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Structural mechanism of the ph ...... DC1 forkhead-associated domain

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Structural mechanism of the ph ...... DC1 forkhead-associated domain

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Structural mechanism of the ph ...... DC1 forkhead-associated domain

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Structural mechanism of the ph ...... DC1 forkhead-associated domain

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Structural mechanism of the ph ...... DC1 forkhead-associated domain

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Structural mechanism of the ph ...... DC1 forkhead-associated domain

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Nucleic Acids Research

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Structural mechanism of the ph ...... DC1 forkhead-associated domain

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Bo Xu

http://www.w3.org/2001/XMLSchema#string

Chunying Yang

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David F Stern

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Hongchang Zhao

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Ji Liao

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Jing Li

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Jinping Liu

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Keqiong Ye

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Shukun Luo

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Xingzhi Xu

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P2860

MDC1 is a mediator of the mammalian DNA damage checkpoint

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

PHENIX: a comprehensive Python-based system for macromolecular structure solution

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3898-912

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10.1093/NAR/GKR1296

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9

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40

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phosphorylation

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