MDC1 is a mediator of the mammalian DNA damage checkpoint
about
Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinomaCK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage responseMicrocephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repairRNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assemblyThe stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathwayA divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatinATM-dependent phosphorylation of ATF2 is required for the DNA damage responseDepletion of nuclear histone H2A variants is associated with chronic DNA damage signaling upon drug-evoked senescence of human somatic cellsRNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sitesRAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sitesWSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activityThe Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaksPhospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damageThe histone demethylase LSD1/KDM1A promotes the DNA damage responseMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionMammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaksRegulatory motifs in Chk1BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repairBRCT domains: easy as one, two, threeThe ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair responseOrchestration of the DNA-damage response by the RNF8 ubiquitin ligaseCep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationCdc7-Dbf4 and the human S checkpoint response to UVCMre11 assembles linear DNA fragments into DNA damage signaling complexesBRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolutionThe Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondiiActivation of the DNA Damage Response by RNA VirusesRole of Deubiquitinating Enzymes in DNA RepairA Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage ResponseNovel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2Functional Role of G9a Histone Methyltransferase in CancerFunctional Role of NBS1 in Radiation Damage Response and Translesion DNA SynthesisAcetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitroHuman RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaksStructural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repairγH2A binds Brc1 to maintain genome integrity during S-phaseDual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain
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MDC1 is a mediator of the mammalian DNA damage checkpoint
description
2003 nî lūn-bûn
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2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
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2003年の論文
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2003年論文
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2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
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2003年论文
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name
MDC1 is a mediator of the mammalian DNA damage checkpoint
@ast
MDC1 is a mediator of the mammalian DNA damage checkpoint
@en
MDC1 is a mediator of the mammalian DNA damage checkpoint
@en-gb
MDC1 is a mediator of the mammalian DNA damage checkpoint
@nl
type
label
MDC1 is a mediator of the mammalian DNA damage checkpoint
@ast
MDC1 is a mediator of the mammalian DNA damage checkpoint
@en
MDC1 is a mediator of the mammalian DNA damage checkpoint
@en-gb
MDC1 is a mediator of the mammalian DNA damage checkpoint
@nl
prefLabel
MDC1 is a mediator of the mammalian DNA damage checkpoint
@ast
MDC1 is a mediator of the mammalian DNA damage checkpoint
@en
MDC1 is a mediator of the mammalian DNA damage checkpoint
@en-gb
MDC1 is a mediator of the mammalian DNA damage checkpoint
@nl
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MDC1 is a mediator of the mammalian DNA damage checkpoint
@en
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A Malcolm R Taylor
Colin R Bignell
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10.1038/NATURE01446
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2003-02-27T00:00:00Z
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1021229868