Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation
about
High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activityThread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of AT base pairs and cross-linking of DNA duplexesThe C-kit receptor-mediated signal transduction and tumor-related diseasesConformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale.G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD.A tetrahelical DNA fold adopted by tandem repeats of alternating GGG and GCG tracts.Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: might dog be used as a model for human disease?A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands.A Personal History of Quadruplex-Small Molecule Targeting.Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models.Isothermal folding of G-quadruplexes.Extended molecular dynamics of a c-kit promoter quadruplex.Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis.Binding of G-quadruplexes to the N-terminal recognition domain of the RNA helicase associated with AU-rich element (RHAU).Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes.G-quadruplexes incorporating modified constituents: a review.G-quadruplex interacting small molecules and drugs: from bench toward bedside.Synthesis and Evaluation of Quinazolone Derivatives as a New Class of c-KIT G-Quadruplex Binding Ligands.An investigation of G-quadruplex structural polymorphism in the human telomere using a combined approach of hydrodynamic bead modeling and molecular dynamics simulation.Loop flexibility in human telomeric quadruplex small-molecule complexes.Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellitesFlexibility and structural conservation in a c-KIT G-quadruplex.Biophysical characterization of G-quadruplex forming FMR1 mRNA and of its interactions with different fragile X mental retardation protein isoforms.Calculation of hydrodynamic properties for G-quadruplex nucleic acid structures from in silico bead models.Tuning the stereoselectivity of a DNA-catalyzed michael addition through covalent modification.Distinct differences in metal ion specificity of RNA and DNA G-quadruplexes.Double stranded promoter region of BRAF undergoes to structural rearrangement in nearly physiological conditions.Catalysis of Michael Additions by Covalently Modified G-Quadruplex DNA.Quadruplexes in 'Dicty': crystal structure of a four-quartet G-quadruplex formed by G-rich motif found in the Dictyostelium discoideum genome.Controlling interfacial electron transfer and electrocatalysis by pH- or ion-switchable DNA monolayer-modified electrodes
P2860
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P2860
Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Crystal structure of a c-kit p ...... maintaining loop conformation
@ast
Crystal structure of a c-kit p ...... maintaining loop conformation
@en
Crystal structure of a c-kit p ...... maintaining loop conformation
@nl
type
label
Crystal structure of a c-kit p ...... maintaining loop conformation
@ast
Crystal structure of a c-kit p ...... maintaining loop conformation
@en
Crystal structure of a c-kit p ...... maintaining loop conformation
@nl
prefLabel
Crystal structure of a c-kit p ...... maintaining loop conformation
@ast
Crystal structure of a c-kit p ...... maintaining loop conformation
@en
Crystal structure of a c-kit p ...... maintaining loop conformation
@nl
P2093
P2860
P356
P1476
Crystal structure of a c-kit p ...... maintaining loop conformation
@en
P2093
Anthony P Reszka
Dengguo Wei
Gary N Parkinson
P2860
P304
P356
10.1093/NAR/GKS023
P407
P577
2012-05-01T00:00:00Z