Quadruplex DNA: sequence, topology and structure - Test2 - elhamkhani - TriplyDB

Quadruplex DNA: sequence, topology and structure

Quadruplex DNA: sequence, topology and structure

http://www.wikidata.org/entity/Q22065978

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Stimulation of gross chromosomal rearrangements by the human CEB1 and CEB25 minisatellites in Saccharomyces cerevisiae depends on G-quadruplexes or Cdc13 The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary 5'-UTR RNA G-quadruplexes: translation regulation and targeting In vivo veritas: using yeast to probe the biological functions of G-quadruplexes Methods for Improving Aptamer Binding Affinity G-quadruplexes and their regulatory roles in biology Molecular dynamics simulations of G-DNA and perspectives on the simulation of nucleic acid structures Atomistic picture for the folding pathway of a hybrid-1 type human telomeric DNA G-quadruplex Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution Structure of the Human Telomere in K + Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics Solution Structure of a Unique G-Quadruplex Scaffold Adopted by a Guanosine-Rich Human Intronic Sequence A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity A minimal i-motif stabilized by minor groove G:T:G:T tetrads RecA-Binding pilE G4 Sequence Essential for Pilin Antigenic Variation Forms Monomeric and 5′ End-Stacked Dimeric Parallel G-Quadruplexes Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity Crystallographic analysis of an RNA polymerase σ-subunit fragment complexed with −10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein–ssDNA complexes Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity Monomer-dimer equilibrium for the 5'-5' stacking of propeller-type parallel-stranded G-quadruplexes: NMR structural study A G-quadruplex–containing RNA activates fluorescence in a GFP-like fluorophore Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome Characterization of the intramolecular G-quadruplex promoting activity of Est1.Integrating Deoxyribozymes into Colorimetric Sensing Platforms G-quadruplexes in pathogens: a common route to virulence control?Snaps and mends: DNA breaks and chromosomal translocations G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome G-Quadruplexes Involving Both Strands of Genomic DNA Are Highly Abundant and Colocalize with Functional Sites in the Human Genome Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus Identification, characterization and application of a G-quadruplex structured DNA aptamer against cancer biomarker protein anterior gradient homolog 2

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Quadruplex DNA: sequence, topology and structure

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Quadruplex DNA: sequence, topology and structure

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Quadruplex DNA: sequence, topology and structure

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Alan K Todd

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Gary N Parkinson

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Creative Commons Attribution-NonCommercial

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Normal human chromosomes have long G-rich telomeric overhangs at one end

Crystal structure of parallel quadruplexes from human telomeric DNA

Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.

Highly prevalent putative quadruplex sequence motifs in human DNA

Prevalence of quadruplexes in the human genome.

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation

Identification of a recurrent breakpoint within the SHANK3 gene in the 22q13.3 deletion syndrome

Vertebrate telomere repeat DNAs favor external loop propeller quadruplex structures in the presence of high concentrations of potassium.

Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal

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10.1093/NAR/GKL655

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