about
The paracaspase MALT1: biological function and potential for therapeutic inhibitionMechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulationStructural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspaseMALT1 is not alone after all: identification of novel paracaspasesThe CBM signalosome: potential therapeutic target for aggressive lymphoma?Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.Monoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interfaceMALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains.Backbone Assignment of the MALT1 Paracaspase by Solution NMR.Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome.Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation.BCL10GFP fusion protein as a substrate for analysis of determinants required for mucosa-associated lymphoid tissue 1 (MALT1)-mediated cleavage.The Paracaspase MALT1.MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivoComparative structural analysis of the caspase family with other clan CD cysteine peptidases.MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression.Probes to monitor activity of the paracaspase MALT1.The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome.A primer on caspase mechanisms.NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy.Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions.Autocleavage of the paracaspase MALT1 at Arg-781 attenuates NF-κB signaling and regulates the growth of activated B-cell like diffuse large B-cell lymphoma cells.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structural determinants of MALT1 protease activity
@ast
Structural determinants of MALT1 protease activity
@en
Structural determinants of MALT1 protease activity
@nl
type
label
Structural determinants of MALT1 protease activity
@ast
Structural determinants of MALT1 protease activity
@en
Structural determinants of MALT1 protease activity
@nl
prefLabel
Structural determinants of MALT1 protease activity
@ast
Structural determinants of MALT1 protease activity
@en
Structural determinants of MALT1 protease activity
@nl
P2093
P1476
Structural determinants of MALT1 protease activity
@en
P2093
Allan D'Arcy
Anna Bernardi
Arnaud Decock
Felix Freuler
Frederic Bornancin
Frederic Villard
Juliano Alves
Jutta Blank
Lukas Leder
Martin Renatus
P356
10.1016/J.JMB.2012.02.018
P407
P577
2012-02-23T00:00:00Z