Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation
about
Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stageStructures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactionsEffects of Glycosylation on the Enzymatic Activity and Mechanisms of ProteasesVacuolar processing enzyme in plant programmed cell deathButelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesisBiochemical, transcriptomic and proteomic analyses of digestion in the scorpion Tityus serrulatus: insights into function and evolution of digestion in an ancient arthropodInhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.An evolutionary analysis of antigen processing and presentation across different timescales reveals pervasive selection.The asparaginyl endopeptidase legumain is essential for functional recovery after spinal cord injury in adult zebrafish.Trichomonas vaginalis Cysteine Proteinases: Iron Response in Gene Expression and Proteolytic Activity.Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome.The Amborella vacuolar processing enzyme family.Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.Comparative transcriptomics of elasmobranchs and teleosts highlight important processes in adaptive immunity and regional endothermy.M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphomaActivation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain.Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis.Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges.Comparative structural analysis of the caspase family with other clan CD cysteine peptidases.Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment.Macrocyclization by asparaginyl endopeptidases.Legumain is activated in macrophages during pancreatitis.Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations.Structure and mechanism of an aspartimide-dependent peptide ligase in human legumain.Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase.The human anti-HIV antibodies 2F5, 2G12, and PG9 differ in their susceptibility to proteolytic degradation: down-regulation of endogenous serine and cysteine proteinase activities could improve antibody production in plant-based expression platformsTwo Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S.Structural basis of ribosomal peptide macrocyclization in plants.Crystal structure of plant legumain reveals a unique two-chain state with pH-dependent activity regulation.A primer on caspase mechanisms.Structural analyses of Arabidopsis thaliana legumain γ reveal the differential recognition and processing of proteolysis and ligation substrates.Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases.Leveraging Physiology for Precision Drug DeliveryBDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT
P2860
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P2860
Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation
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2013 nî lūn-bûn
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2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
@zh-hant
2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
Mechanistic and structural stu ...... ation pathways, and regulation
@ast
Mechanistic and structural stu ...... ation pathways, and regulation
@en
Mechanistic and structural stu ...... ation pathways, and regulation
@nl
type
label
Mechanistic and structural stu ...... ation pathways, and regulation
@ast
Mechanistic and structural stu ...... ation pathways, and regulation
@en
Mechanistic and structural stu ...... ation pathways, and regulation
@nl
prefLabel
Mechanistic and structural stu ...... ation pathways, and regulation
@ast
Mechanistic and structural stu ...... ation pathways, and regulation
@en
Mechanistic and structural stu ...... ation pathways, and regulation
@nl
P2860
P3181
P356
P1476
Mechanistic and structural stu ...... ation pathways, and regulation
@en
P2093
Elfriede Dall
P2860
P304
P3181
P356
10.1073/PNAS.1300686110
P407
P577
2013-07-02T00:00:00Z