A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation
about
Conformational dynamics of stem II of the U2 snRNA.Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.ChSeq: A database of chameleon sequences.A mutation in a splicing factor that causes retinitis pigmentosa has a transcriptome-wide effect on mRNA splicing.RNA catalyses nuclear pre-mRNA splicingPRPF8 defects cause missplicing in myeloid malignancies.Mechanisms and Regulation of Alternative Pre-mRNA SplicingAuto-inhibitory Mechanism of the Human Mitochondrial RNase P Protein Complex.A day in the life of the spliceosomeStructural studies of the spliceosome: zooming into the heart of the machine.Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site.The molecular pathogenesis of the myelodysplastic syndromes.Activating the branch-forming splicing pathway by reengineering the ribozyme component of a natural group II intron.A network biology approach to understanding the importance of chameleon proteins in human physiology and pathology.Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency.An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8.A close-up look at the spliceosome, at last.Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength.Toggling in the spliceosome.Variants in the PRPF8 Gene are Associated with Glaucoma.
P2860
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P2860
A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
A conformational switch in PRP ...... romotes pre-mRNA exon ligation
@ast
A conformational switch in PRP ...... romotes pre-mRNA exon ligation
@en
A conformational switch in PRP ...... romotes pre-mRNA exon ligation
@nl
type
label
A conformational switch in PRP ...... romotes pre-mRNA exon ligation
@ast
A conformational switch in PRP ...... romotes pre-mRNA exon ligation
@en
A conformational switch in PRP ...... romotes pre-mRNA exon ligation
@nl
prefLabel
A conformational switch in PRP ...... romotes pre-mRNA exon ligation
@ast
A conformational switch in PRP ...... romotes pre-mRNA exon ligation
@en
A conformational switch in PRP ...... romotes pre-mRNA exon ligation
@nl
P2093
P2860
P356
P1476
A conformational switch in PRP ...... romotes pre-mRNA exon ligation
@en
P2093
Andrew M MacMillan
Dustin B Ritchie
Jonathan P Staley
Karim A Atta
Matthew J Schellenberg
Paul LaPointe
P2860
P2888
P304
P356
10.1038/NSMB.2556
P577
2013-05-19T00:00:00Z
P5875
P6179
1009314308