Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING - Test2 - elhamkhani - TriplyDB

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

http://www.wikidata.org/entity/Q27678540

about

Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.Cytosolic Innate Immune Sensing and Signaling upon Infection Ubiquitin signaling in immune responses The Next Hurdle in Cancer Immunotherapy: Overcoming the Non-T-Cell-Inflamed Tumor Microenvironment Recognition of cytosolic DNA by cGAS and other STING-dependent sensors The STING pathway and the T cell-inflamed tumor microenvironment Crosstalk between Mycobacterium tuberculosis and the host cell Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry–related pockets New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16 DNA sensor cGAS-mediated immune recognition Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease Bacterial recognition pathways that lead to inflammasome activation RIG-I in RNA virus recognition Rat and human STINGs profile similarly towards anticancer/antiviral compounds Role of the HIN domain in regulation of innate immune responses Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity.Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.Crosstalk Between Apoptosis and Autophagy: Environmental Genotoxins, Infection, and Innate Immunity.Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens.Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity.Cyclic GMP-AMP displays mucosal adjuvant activity in mice Intracellular immunity: finding the enemy within--how cells recognize and respond to intracellular pathogens Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway.Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.Interferon-stimulated genes: a complex web of host defenses.The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.Control of bacterial exoelectrogenesis by c-AMP-GMP.

P2860

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P2860

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

http://www.wikidata.org/entity/Q27678540

description

2013 nî lūn-bûn

@nan

2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հուլիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Cyclic GMP-AMP Containing Mixe ...... High-Affinity Ligand for STING

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Cyclic GMP-AMP Containing Mixe ...... High-Affinity Ligand for STING

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Cyclic GMP-AMP Containing Mixe ...... High-Affinity Ligand for STING

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Cyclic GMP-AMP Containing Mixe ...... High-Affinity Ligand for STING

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Cyclic GMP-AMP Containing Mixe ...... High-Affinity Ligand for STING

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Cyclic GMP-AMP Containing Mixe ...... High-Affinity Ligand for STING

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Cyclic GMP-AMP Containing Mixe ...... High-Affinity Ligand for STING

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Cyclic GMP-AMP Containing Mixe ...... High-Affinity Ligand for STING

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Heping Shi

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Lijun Sun

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Xu Zhang

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Xuewu Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

Cyclic di-GMP sensing via the innate immune signaling protein STING

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

STING is a direct innate immune sensor of cyclic di-GMP

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

The structural basis for the sensing and binding of cyclic di-GMP by STING

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes

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10.1016/J.MOLCEL.2013.05.022

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2'-O,5'-O-((adenosine-3'-O,5'-O-diyl)bisphosphinico)guanosine

cyclic-GMP-AMP binding

Transmembrane protein 173

P932

3808999

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