Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling - Test2 - elhamkhani - TriplyDB

Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling

Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling

http://www.wikidata.org/entity/Q27678806

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Substrate specificity of the ubiquitin and Ubl proteases Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting Viewing protein fitness landscapes through a next-gen lens.Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast Variational cross-validation of slow dynamical modes in molecular kinetics.System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.Using protein motion to read, write, and erase ubiquitin signals.Allosteric switch regulates protein-protein binding through collective motion.DUBs, the regulation of cell identity and disease.Adaptability of protein structures to enable functional interactions and evolutionary implications.Downregulation of ubiquitin-specific protease 14 (USP14) inhibits breast cancer cell proliferation and metastasis, but promotes apoptosis.Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.MicroRNA-17 Suppresses TNF-α Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts.A designed conformational shift to control protein binding specificity.USP14 de-ubiquitinates vimentin and miR-320a modulates USP14 and vimentin to contribute to malignancy in gastric cancer cells.Conformational Dynamics Modulate Activation of the Ubiquitin Conjugating Enzyme Ube2g2.Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis.Dynamic Modulation of Binding Affinity as a Mechanism for Regulating Interferon Signaling.A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms.Specific targeting of the deubiquitinase and E3 ligase families with engineered ubiquitin variants.Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif.Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes.

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P2860

Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling

http://www.wikidata.org/entity/Q27678806

description

2013 nî lūn-bûn

@nan

2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հուլիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Conformational dynamics contro ...... nd influence in vivo signaling

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Conformational dynamics contro ...... nd influence in vivo signaling

@en

Conformational dynamics contro ...... nd influence in vivo signaling

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type

label

Conformational dynamics contro ...... nd influence in vivo signaling

@ast

Conformational dynamics contro ...... nd influence in vivo signaling

@en

Conformational dynamics contro ...... nd influence in vivo signaling

@nl

prefLabel

Conformational dynamics contro ...... nd influence in vivo signaling

@ast

Conformational dynamics contro ...... nd influence in vivo signaling

@en

Conformational dynamics contro ...... nd influence in vivo signaling

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PNAS.1302407110

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Proceedings of the National Academy of Sciences of the United States of America

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Conformational dynamics contro ...... nd influence in vivo signaling

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Aaron H Phillips

http://www.w3.org/2001/XMLSchema#string

Christian N Cunningham

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Christine Tam

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Jacob E Corn

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Jeremy M Murray

http://www.w3.org/2001/XMLSchema#string

Lijuan Zhou

http://www.w3.org/2001/XMLSchema#string

Peter S Liu

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Wayne J Fairbrother

http://www.w3.org/2001/XMLSchema#string

William F Forrest

http://www.w3.org/2001/XMLSchema#string

Yingnan Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

Systematic and quantitative assessment of the ubiquitin-modified proteome

Consistent blind protein structure generation from NMR chemical shift data

Antibody multispecificity mediated by conformational diversity

Structure and dynamics of a molten globular enzyme

Mutations in the Hydrophobic Core of Ubiquitin Differentially Affect Its Recognition by Receptor Proteins

Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution

Hidden alternative structures of proline isomerase essential for catalysis

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

Solution structure of a minor and transiently formed state of a T4 lysozyme mutant

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scholarly article

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10.1073/PNAS.1302407110

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28

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110

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Donald S Kirkpatrick

Elizabeth Helgason

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2013-07-09T00:00:00Z

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242017696

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23801757

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3710810

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