Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*
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RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic traffickingRecruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and AutophagosomesMembrane Tethering Complexes in the Endosomal SystemReconciling the regulatory role of Munc18 proteins in SNARE-complex assemblySyntaxin binding mechanism and disease-causing mutations in Munc18-2Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasisMutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptomsAn extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly.SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18.Membrane tetheringThe SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex.Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans.Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33A(D251E) mutation.CAPS and Munc13: CATCHRs that SNARE VesiclesFunctional homologies in vesicle tethering.Chaperoning SNARE assembly and disassemblyDeep brain stimulation of the subthalamic nucleus preferentially alters the translational profile of striatopallidal neurons in an animal model of Parkinson's disease.Distinct roles of the two VPS33 proteins in the endolysosomal system in Caenorhabditis elegans.Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes.The Habc domain of the SNARE Vam3 interacts with the HOPS tethering complex to facilitate vacuole fusion.ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination.Structural identification of the Vps18 β-propeller reveals a critical role in the HOPS complex stability and function.A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly.CATCHR, HOPS and CORVET tethering complexes share a similar architecture.Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis.
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P2860
Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
Crystal Structures of the Sec1 ...... Sorting (HOPS) Subunit Vps16*
@ast
Crystal Structures of the Sec1 ...... Sorting (HOPS) Subunit Vps16*
@en
Crystal Structures of the Sec1 ...... Sorting (HOPS) Subunit Vps16*
@nl
type
label
Crystal Structures of the Sec1 ...... Sorting (HOPS) Subunit Vps16*
@ast
Crystal Structures of the Sec1 ...... Sorting (HOPS) Subunit Vps16*
@en
Crystal Structures of the Sec1 ...... Sorting (HOPS) Subunit Vps16*
@nl
prefLabel
Crystal Structures of the Sec1 ...... Sorting (HOPS) Subunit Vps16*
@ast
Crystal Structures of the Sec1 ...... Sorting (HOPS) Subunit Vps16*
@en
Crystal Structures of the Sec1 ...... Sorting (HOPS) Subunit Vps16*
@nl
P2093
P2860
P3181
P1433
P1476
Crystal Structures of the Sec1 ...... Sorting (HOPS) Subunit Vps16*
@en
P2093
Frederick M Hughson
Philip D Jeffrey
Richard W Baker
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0067409
P407
P577
2013-01-01T00:00:00Z