Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin
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Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infectionsEndotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity.XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death.The Impact of Aminoglycosides on the Dynamics of Translation ElongationIdentification of the molecular attributes required for aminoglycoside activity against Leishmania4′-O-substitutions determine selectivity of aminoglycoside antibioticsRibosome. The complete structure of the 55S mammalian mitochondrial ribosomeMitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochleaStructural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.Gentamicin differentially alters cellular metabolism of cochlear hair cells as revealed by NAD(P)H fluorescence lifetime imaging.Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo.Assessment of nutrient supplement to reduce gentamicin-induced ototoxicity.A novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity.The mitochondrion: a perpetrator of acquired hearing loss.Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.Designer aminoglycosides prevent cochlear hair cell loss and hearing lossNew trends in aminoglycosides use.Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.The evolving role of chemical synthesis in antibacterial drug discovery.Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutationsIn vivo efficacy of apramycin in murine infection models.Validation of a High-Throughput Screening Assay for Identification of Adjunctive and Directly Acting Antimicrobials Targeting Carbapenem-Resistant Enterobacteriaceae.In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibioticsd-Methionine reduces tobramycin-induced ototoxicity without antimicrobial interference in animal models.Frequency and Demographics of Gentamicin Use.Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitorsMitochondrial m.1584A 12S m62A rRNA methylation in families with m.1555A>G associated hearing loss.Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases.Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance.Analysis of ribosomal inter-subunit sites as targets for complementary oligonucleotides.New treatment options for hearing loss.Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinery of Old Drugs.Detection and Quantification of Ribosome Inhibition by Aminoglycoside Antibiotics in Living Bacteria Using an Orthogonal Ribosome-Controlled Fluorescent ReporterParallel pathways in the biosynthesis of aminoglycoside antibiotics.Targeting Nonsense Mutations in Diseases with Translational Read-Through-Inducing Drugs (TRIDs).Protecting Mammalian Hair Cells from Aminoglycoside-Toxicity: Assessing Phenoxybenzamine's Potential.Importance of the 6'-hydroxy group and its configuration for apramycin activity.N6', N6''', and O4' Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity.Alternative synthesis and antibacterial evaluation of 1,5-dideoxy-1,5-imino-L-rhamnitol.Aminoglycoside-modifying enzymes determine the innate susceptibility to aminoglycoside antibiotics in rapidly growing mycobacteria.
P2860
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P2860
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin
@ast
Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin
@en
Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin
@nl
type
label
Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin
@ast
Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin
@en
Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin
@nl
prefLabel
Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin
@ast
Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin
@en
Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin
@nl
P2093
P2860
P356
P1476
Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin
@en
P2093
Andrea Vasella
Chyan Leong Ng
Dmitri Shcherbakov
Déborah Perez-Fernandez
Erik C Böttger
Jochen Schacht
Martin Meyer
Rashid Akbergenov
Srinivas R Dubbaka
P2860
P304
P356
10.1073/PNAS.1204073109
P407
P577
2012-07-03T00:00:00Z