Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin - Test2 - elhamkhani - TriplyDB

Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

http://www.wikidata.org/entity/Q27681169

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Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity.XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death.The Impact of Aminoglycosides on the Dynamics of Translation Elongation Identification of the molecular attributes required for aminoglycoside activity against Leishmania 4′-O-substitutions determine selectivity of aminoglycoside antibiotics Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.Gentamicin differentially alters cellular metabolism of cochlear hair cells as revealed by NAD(P)H fluorescence lifetime imaging.Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo.Assessment of nutrient supplement to reduce gentamicin-induced ototoxicity.A novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity.The mitochondrion: a perpetrator of acquired hearing loss.Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.Designer aminoglycosides prevent cochlear hair cell loss and hearing loss New trends in aminoglycosides use.Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.The evolving role of chemical synthesis in antibacterial drug discovery.Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations In vivo efficacy of apramycin in murine infection models.Validation of a High-Throughput Screening Assay for Identification of Adjunctive and Directly Acting Antimicrobials Targeting Carbapenem-Resistant Enterobacteriaceae.In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics d-Methionine reduces tobramycin-induced ototoxicity without antimicrobial interference in animal models.Frequency and Demographics of Gentamicin Use.Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors Mitochondrial m.1584A 12S m62A rRNA methylation in families with m.1555A>G associated hearing loss.Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases.Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance.Analysis of ribosomal inter-subunit sites as targets for complementary oligonucleotides.New treatment options for hearing loss.Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinery of Old Drugs.Detection and Quantification of Ribosome Inhibition by Aminoglycoside Antibiotics in Living Bacteria Using an Orthogonal Ribosome-Controlled Fluorescent Reporter Parallel pathways in the biosynthesis of aminoglycoside antibiotics.Targeting Nonsense Mutations in Diseases with Translational Read-Through-Inducing Drugs (TRIDs).Protecting Mammalian Hair Cells from Aminoglycoside-Toxicity: Assessing Phenoxybenzamine's Potential.Importance of the 6'-hydroxy group and its configuration for apramycin activity.N6', N6''', and O4' Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity.Alternative synthesis and antibacterial evaluation of 1,5-dideoxy-1,5-imino-L-rhamnitol.Aminoglycoside-modifying enzymes determine the innate susceptibility to aminoglycoside antibiotics in rapidly growing mycobacteria.

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P2860

Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

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2012 nî lūn-bûn

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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2012年の論文

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Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin

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Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin

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Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin

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PNAS.1204073109

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Proceedings of the National Academy of Sciences of the United States of America

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Dissociation of antibacterial ...... d 2-deoxystreptamine apramycin

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Andrea Vasella

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Chyan Leong Ng

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Dmitri Shcherbakov

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Déborah Perez-Fernandez

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Erik C Böttger

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Jing Xie

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Jochen Schacht

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Martin Meyer

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Rashid Akbergenov

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Srinivas R Dubbaka

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P2860

New developments in aminoglycoside therapy and ototoxicity

Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding

Structure of the 30S ribosomal subunit

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site

The in vitro activity of apramycin, a new aminocyclitol antibiotic

Interaction of antibiotics with functional sites in 16S ribosomal RNA

Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea.

Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss.

Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity.

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109

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Venkatraman Ramakrishnan

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2012-07-03T00:00:00Z

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235606679

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