Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection
about
Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksMechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repairA versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real timeAluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.The genetic and biochemical basis of FANCD2 monoubiquitinationThe Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCLMutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2.UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells.The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2.Advances in the understanding of Fanconi Anemia Complementation Group D2 Protein (FANCD2) in human cancer.Specificity and disease in the ubiquitin systemRecent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia.Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism.The ubiquitin conjugating enzyme, TaU4 regulates wheat defence against the phytopathogen Zymoseptoria tritici.Architecture of the ubiquitylation module of the yeast Ccr4-Not complex.The ubiquitin-conjugating enzyme, UbcM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of E2 and Lys48 of ubiquitin.Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.Modularized functions of the Fanconi anemia core complex.Protein-protein interactions in paralogues: Electrostatics modulates specificity on a conserved steric scaffold.Crystal structure and SUMO binding of Slx1-Slx4 complex.Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complexS. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.
P2860
Q26784027-73C4219B-50F8-4F9B-9462-9E25BD13B2FDQ28067393-D2FD3F75-CA49-4C75-9087-CA96BBFC36FFQ28115456-1576CF9A-8F68-4650-BCD4-3AE238E2225BQ28253043-AB6BC866-20A2-404D-B0A5-3D1D5B025051Q30371243-4D53931C-79D3-4950-A630-2BF90FE52A0AQ33735561-78289193-EF71-470A-A461-A7E119E8C8B8Q34483757-C80D2126-83B8-40D9-B031-31F16C9FF8F8Q35689795-7D0944E3-0BAF-4F46-8069-98E87A4BFC91Q35836818-D743CD07-CB3A-430A-A4E8-AD8BD17AC4B4Q37099432-967C8E2D-9F86-4A73-B1AA-A084A2B01E1CQ37581621-FA549FEA-CBCF-4431-9796-4AF829D93978Q37607318-1EB72EDC-E8E8-4D3C-8D4F-24959F899031Q38660676-19D797C1-E848-4B31-864D-3ED0726DD89EQ38728113-22C26454-74F5-45B9-9789-01A622C14580Q38985539-FED1DBE5-3F53-4890-A5A5-7125941BED03Q39149390-C617CD8F-812F-4B86-9379-03B32AFFB7BCQ40531090-749E0C7A-3B92-4199-899B-3DAB55F58B18Q40660615-EDF2EF36-53A3-434F-A5C0-706AF18A3521Q41277138-316C2F82-DA9D-43D0-96CB-DCE16B999C7EQ41791632-B42F8413-9844-45FC-855A-910DADE94B9AQ41899570-D5FCDEC5-E38F-455F-B415-5D2A0A88821AQ41915735-9317F447-F968-4A91-BB6D-D28837DB522FQ42706696-62017328-7AE2-4C02-9424-8EA529F192EEQ43069093-910D10F0-2C91-4A75-B8EA-EF18768384AAQ46144594-99158795-2105-415A-834D-98F6479DFE58Q50287474-DD9FFEA9-BCB7-48DB-AFBE-AF2C527CB663Q51152129-2D9BC649-6ED1-46C2-8DCC-7E6AA5A3C52EQ52329489-2E7FAAA8-0638-46D5-A584-41131FFFB917Q55303071-4554EB5C-8E05-44B9-8BC7-F5FFEA1424FE
P2860
Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection
description
2014 nî lūn-bûn
@nan
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@ast
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@en
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@en-gb
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@nl
type
label
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@ast
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@en
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@en-gb
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@nl
prefLabel
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@ast
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@en
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@en-gb
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@nl
P2093
P2860
P921
P3181
P1433
P1476
Structure of the Human FANCL R ...... nts of Cognate E3-E2 Selection
@en
P2093
Andrew Purkiss
Charlotte Hodson
Helen Walden
P2860
P304
P3181
P356
10.1016/J.STR.2013.12.004
P577
2014-02-04T00:00:00Z