Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis
about
Principles of allosteric interactions in cell signalingStructure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 SelectionThe Generation and Exploitation of Protein Mutability Landscapes for Enzyme EngineeringRheostats and toggle switches for modulating protein functionViewing protein fitness landscapes through a next-gen lens.High-throughput profiling of point mutations across the HIV-1 genome.Software for the analysis and visualization of deep mutational scanning data.Molecular Determinants of Mutant Phenotypes, Inferred from Saturation Mutagenesis DataA comprehensive, high-resolution map of a gene's fitness landscapeAn experimentally determined evolutionary model dramatically improves phylogenetic fit.High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.An experimentally informed evolutionary model improves phylogenetic fit to divergent lactamase homologsA massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutationsMassively parallel determination and modeling of endonuclease substrate specificityMassively parallel single-amino-acid mutagenesisMeasuring the activity of protein variants on a large scale using deep mutational scanning.Deep mutational scanning: a new style of protein scienceHow structural and physicochemical determinants shape sequence constraints in a functional enzymeSystematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral MutationsDe novo assembly and next-generation sequencing to analyse full-length gene variants from codon-barcoded libraries.Massively Parallel Functional Analysis of BRCA1 RING Domain Variants.Generating High-Accuracy Peptide-Binding Data in High Throughput with Yeast Surface Display and SORTCERY.Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.UBE4B targets phosphorylated p53 at serines 15 and 392 for degradationComprehensive Analysis of the SUL1 Promoter of Saccharomyces cerevisiaeUsing Evolution to Guide Protein Engineering: The Devil IS in the Details.A novel test for selection on cis-regulatory elements reveals positive and negative selection acting on mammalian transcriptional enhancers.UBE4B protein couples ubiquitination and sorting machineries to enable epidermal growth factor receptor (EGFR) degradation.Engineering allostery.A statistical framework for analyzing deep mutational scanning data.Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions.The power of multiplexed functional analysis of genetic variants.Mutation effects predicted from sequence co-variation.Deep sequencing methods for protein engineering and design.The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair.High-Throughput Assays to Assess the Functional Impact of Genetic Variants: A Road Towards Genomic-Driven Medicine.Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.A Subset of Ubiquitin-Conjugating Enzymes Is Essential for Plant Immunity.Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.Mechanism of ubiquitin transfer promoted by TRAF6.
P2860
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P248
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P2860
Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis
description
2013 nî lūn-bûn
@nan
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
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2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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name
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@ast
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@en
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@en-gb
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@nl
type
label
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@ast
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@en
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@en-gb
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@nl
prefLabel
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@ast
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@en
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@en-gb
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@nl
P2093
P2860
P921
P3181
P356
P1476
Activity-enhancing mutations i ...... by high-throughput mutagenesis
@en
P2093
Douglas M Fowler
Helen J Kim
Jonathan N Pruneda
Joseph B Hiatt
Lea M Starita
Peter S Brzovic
Rachel E Klevit
Russell S Lo
Stanley Fields
P2860
P304
P3181
P356
10.1073/PNAS.1303309110
P407
P50
P577
2013-04-02T00:00:00Z