Three-Dimensional Structure and Determinants of Stability of the Iron–Sulfur Cluster Scaffold Protein IscU from Escherichia coli
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NMRFAM-SDF: a protein structure determination frameworkRole of IscX in iron-sulfur cluster biogenesis in Escherichia colipH-induced conformational change of IscU at low pH correlates with protonation/deprotonation of two conserved histidine residues.The specialized Hsp70 (HscA) interdomain linker binds to its nucleotide-binding domain and stimulates ATP hydrolysis in both cis and trans configurations.Tangled web of interactions among proteins involved in iron-sulfur cluster assembly as unraveled by NMR, SAXS, chemical crosslinking, and functional studies.The Complex Energy Landscape of the Protein IscUMetamorphic protein IscU changes conformation by cis-trans isomerizations of two peptidyl-prolyl peptide bonds.Protection of scaffold protein Isu from degradation by the Lon protease Pim1 as a component of Fe-S cluster biogenesis regulationHuman mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).Mammalian Fe-S proteins: definition of a consensus motif recognized by the co-chaperone HSC20Metamorphic protein IscU alternates conformations in the course of its role as the scaffold protein for iron-sulfur cluster biosynthesis and delivery.Biogenesis of [Fe-S] cluster in Firmicutes: an unexploited field of investigation.Posttranslational control of the scaffold for Fe-S cluster biogenesis as a compensatory regulatory mechanism.Understanding the role of dynamics in the iron sulfur cluster molecular machine.In vitro characterization of a novel Isu homologue from Drosophila melanogaster for de novo FeS-cluster formation.Glutathione-complexed [2Fe-2S] clusters function in Fe-S cluster storage and trafficking.The NMR contribution to protein-protein networking in Fe-S protein maturation.Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activityNMR as a Tool to Investigate the Processes of Mitochondrial and Cytosolic Iron-Sulfur Cluster Biosynthesis
P2860
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P2860
Three-Dimensional Structure and Determinants of Stability of the Iron–Sulfur Cluster Scaffold Protein IscU from Escherichia coli
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2012 nî lūn-bûn
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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2012 թվականի հուլիսին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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Three-Dimensional Structure an ...... ein IscU from Escherichia coli
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Three-Dimensional Structure an ...... ein IscU from Escherichia coli
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Three-Dimensional Structure an ...... ein IscU from Escherichia coli
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Three-Dimensional Structure an ...... ein IscU from Escherichia coli
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Three-Dimensional Structure an ...... ein IscU from Escherichia coli
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Three-Dimensional Structure an ...... ein IscU from Escherichia coli
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Three-Dimensional Structure an ...... ein IscU from Escherichia coli
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Three-Dimensional Structure an ...... ein IscU from Escherichia coli
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Three-Dimensional Structure an ...... ein IscU from Escherichia coli
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P2093
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Three-Dimensional Structure an ...... ein IscU from Escherichia coli
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P2093
Jin Hae Kim
Marco Tonelli
Taewook Kim
P2860
P304
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P356
10.1021/BI300579P
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P50
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2012-07-17T00:00:00Z