Metamorphic protein IscU alternates conformations in the course of its role as the scaffold protein for iron-sulfur cluster biosynthesis and delivery.
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[2Fe-2S] cluster transfer in iron-sulfur protein biogenesisFrataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondriaRole of IscX in iron-sulfur cluster biogenesis in Escherichia coliNew Techniques for Ancient Proteins: Direct Coupling Analysis Applied on Proteins Involved in Iron Sulfur Cluster BiogenesispH-induced conformational change of IscU at low pH correlates with protonation/deprotonation of two conserved histidine residues.Nucleotide-dependent interactions within a specialized Hsp70/Hsp40 complex involved in Fe-S cluster biogenesis.The diabetes drug target MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/iron regulatory protein 1The role of zinc in the stability of the marginally stable IscU scaffold protein.The specialized Hsp70 (HscA) interdomain linker binds to its nucleotide-binding domain and stimulates ATP hydrolysis in both cis and trans configurations.Tangled web of interactions among proteins involved in iron-sulfur cluster assembly as unraveled by NMR, SAXS, chemical crosslinking, and functional studies.Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.Turning Saccharomyces cerevisiae into a Frataxin-Independent Organism.The Complex Energy Landscape of the Protein IscUArchitecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery: THE SUB-COMPLEX FORMED BY THE IRON DONOR, Yfh1 PROTEIN, AND THE SCAFFOLD, Isu1 PROTEIN.Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).Fe-S cluster biogenesis in Gram-positive bacteria: SufU is a zinc-dependent sulfur transfer protein.Thermodynamic and structural analysis of human NFU conformational chemistry.Identification of drivers for the metamorphic transition of HIV-1 reverse transcriptase.How Do J-Proteins Get Hsp70 to Do So Many Different Things?Understanding the role of dynamics in the iron sulfur cluster molecular machine.Atypical effect of temperature tuning on the insertion of the catalytic iron-sulfur center in a recombinant [FeFe]-hydrogenase.The many faces of proteins.Functional implications of the interaction between HscB and IscU in the biosynthesis of FeS clusters.Zinc and the iron donor frataxin regulate oligomerization of the scaffold protein to form new Fe-S cluster assembly centers.Regulation of human Nfu activity in Fe-S cluster delivery-characterization of the interaction between Nfu and the HSPA9/Hsc20 chaperone complex.ISCU(M108I) and ISCU(D39V) Differ from Wild-Type ISCU in Their Failure To Form Cysteine Desulfurase Complexes Containing Both Frataxin and Ferredoxin.Altered levels of AtHSCB disrupts iron translocation from roots to shoots.Glutathione-complexed [2Fe-2S] clusters function in Fe-S cluster storage and trafficking.Life without Fe-S clusters.Assembly and Transfer of Iron-Sulfur Clusters in the Plastid.Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activityNMR as a Tool to Investigate the Processes of Mitochondrial and Cytosolic Iron-Sulfur Cluster Biosynthesis
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P2860
Metamorphic protein IscU alternates conformations in the course of its role as the scaffold protein for iron-sulfur cluster biosynthesis and delivery.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 January 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Metamorphic protein IscU alter ...... ter biosynthesis and delivery.
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Metamorphic protein IscU alter ...... ter biosynthesis and delivery.
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type
label
Metamorphic protein IscU alter ...... ter biosynthesis and delivery.
@en
Metamorphic protein IscU alter ...... ter biosynthesis and delivery.
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prefLabel
Metamorphic protein IscU alter ...... ter biosynthesis and delivery.
@en
Metamorphic protein IscU alter ...... ter biosynthesis and delivery.
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P2093
P2860
P1433
P1476
Metamorphic protein IscU alter ...... ster biosynthesis and delivery
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P2093
Jameson R Bothe
John L Markley
Marco Tonelli
Ronnie O Frederick
P2860
P304
P356
10.1016/J.FEBSLET.2013.01.003
P407
P577
2013-01-16T00:00:00Z