Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli - Test2 - elhamkhani - TriplyDB

Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli

Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli

http://www.wikidata.org/entity/Q27681431

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Post-expression strategies for structural investigations of membrane proteins.Large-scale production and protein engineering of G protein-coupled receptors for structural studies Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs Structure-guided development of heterodimer-selective GPCR ligands Covalently circularized nanodiscs for studying membrane proteins and viral entry.Characterisation of a cell-free synthesised G-protein coupled receptor Defining thermostability of membrane proteins by western blotting.A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties Peptide ligand recognition by G protein-coupled receptors Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution.Rapid directed evolution of stabilized proteins with cellular high-throughput encapsulation solubilization and screening (CHESS).Stabilization of G protein-coupled receptors by point mutations.Identification of destabilizing and stabilizing mutations of Ste2p, a G protein-coupled receptor in Saccharomyces cerevisiae.A Novel Screening Approach for Optimal and Functional Fusion of T4 Lysozyme in GPCRs.Modeling of the OX1R-orexin-A complex suggests two alternative binding modes.Eukaryotic G protein-coupled receptors as descendants of prokaryotic sodium-translocating rhodopsins.Structural prerequisites for G-protein activation by the neurotensin receptor Structural dynamics and thermostabilization of neurotensin receptor 1 NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands How Can Mutations Thermostabilize G-Protein-Coupled Receptors?Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts.Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding.Toward high-resolution computational design of the structure and function of helical membrane proteins Structure and dynamics of a constitutively active neurotensin receptor.Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of G protein-coupled receptors The receptor concept in 3D: from hypothesis and metaphor to GPCR-ligand structures.Membrane proteins, detergents and crystals: what is the state of the art?Structure and function of G protein-coupled receptor oligomers: implications for drug discovery.Methodological advances: the unsung heroes of the GPCR structural revolution.A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution.Homology-based Modeling of Rhodopsin-like Family Members in the Inactive State: Structural Analysis and Deduction of Tips for Modeling and Optimization.Membrane Protein Production in Escherichia coli: Protocols and Rules.Deep sequencing methods for protein engineering and design.β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop.New approaches towards the understanding of integral membrane proteins: A structural perspective on G protein-coupled receptors.How to Choose the Suitable Template for Homology Modelling of GPCRs: 5-HT7 Receptor as a Test Case.Accurate Prediction of Contact Numbers for Multi-Spanning Helical Membrane Proteins.Accurate and Rigorous Prediction of the Changes in Protein Free Energies in a Large-Scale Mutation Scan.

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Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli

http://www.wikidata.org/entity/Q27681431

description

2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Structure of signaling-compete ...... evolution in Escherichia coli

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Structure of signaling-compete ...... evolution in Escherichia coli

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Structure of signaling-compete ...... evolution in Escherichia coli

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type

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Structure of signaling-compete ...... evolution in Escherichia coli

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Structure of signaling-compete ...... evolution in Escherichia coli

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Structure of signaling-compete ...... evolution in Escherichia coli

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Structure of signaling-compete ...... evolution in Escherichia coli

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Structure of signaling-compete ...... evolution in Escherichia coli

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Structure of signaling-compete ...... evolution in Escherichia coli

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Proceedings of the National Academy of Sciences of the United States of America

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Structure of signaling-compete ...... evolution in Escherichia coli

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Karola M Schlinkmann

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Marco Schütz

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Matthias Hillenbrand

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Pascal Egloff

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Stefanie Balada

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P2860

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Mitosis and inhibition of intracellular transport stimulate palmitoylation of a 62-kD protein

Membrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCR

Crystal structure of the ligand-free G-protein-coupled receptor opsin

Structure of a beta1-adrenergic G-protein-coupled receptor.

Crystal structure of opsin in its G-protein-interacting conformation

Crystal structure of metarhodopsin II

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10.1073/PNAS.1317903111

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6

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111

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Andreas Plückthun

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Alexander Batyuk

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259878165

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24453215

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Escherichia coli

directed evolution

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3926081

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