Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor

Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor

Item
http://www.wikidata.org/entity/Q27683440
Investigational drugs to treat methicillin-resistant Staphylococcus aureusAn ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction.How bacterial pathogens eat host lipids: implications for the development of fatty acid synthesis therapeutics.Direct inhibitors of InhA are active against Mycobacterium tuberculosis.Analysis of Enoyl-Acyl Carrier Protein Reductase Structure and Interactions Yields an Efficient Virtual Screening Approach and Suggests a Potential Allosteric Site.Transient In Vivo Resistance Mechanisms of Burkholderia pseudomallei to Ceftazidime and Molecular Markers for Monitoring Treatment Response.Crystallographic insights into the structure-activity relationships of diazaborine enoyl-ACP reductase inhibitors.Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials.Discovery of a new method for potent drug development using power function of stoichiometry of homomeric biocomplexes or biological nanomotorsRecent Advances in the Rational Design and Optimization of Antibacterial Agents.AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei--Crystal structure, mode of action, and biological activity.Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.Clinical Relevance of Type II Fatty Acid Synthesis Bypass in Staphylococcus aureus.Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase.Better living through chemistry: Addressing emerging antibiotic resistance.Mechanistic insight into acrylate metabolism and detoxification in marine dimethylsulfoniopropionate-catabolizing bacteria.
P2860

Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor

Item
http://www.wikidata.org/entity/Q27683440
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Rational Design of Broad Spect ...... tein (ACP) Reductase Inhibitor
@ast
Rational Design of Broad Spect ...... tein (ACP) Reductase Inhibitor
@en
Rational Design of Broad Spect ...... tein (ACP) Reductase Inhibitor
@nl
type
label
Rational Design of Broad Spect ...... tein (ACP) Reductase Inhibitor
@ast
Rational Design of Broad Spect ...... tein (ACP) Reductase Inhibitor
@en
Rational Design of Broad Spect ...... tein (ACP) Reductase Inhibitor
@nl
prefLabel
Rational Design of Broad Spect ...... tein (ACP) Reductase Inhibitor
@ast
Rational Design of Broad Spect ...... tein (ACP) Reductase Inhibitor
@en
Rational Design of Broad Spect ...... tein (ACP) Reductase Inhibitor
@nl
P1433
P1476
P2093
P2860
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698
P921
P932
P3181
P356
P1433
P1476
Rational Design of Broad Spect ...... tein (ACP) Reductase Inhibitor
@en
P2093
P2860
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698
P921
P932