about
Mycobacterium tuberculosis septum site determining protein, Ssd encoded by rv3660c, promotes filamentation and elicits an alternative metabolic and dormancy stress responseImplications of high level pseudogene transcription in Mycobacterium lepraeSlow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis : Residence Time and in Vivo ActivityTime-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo EfficacyRational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase InhibitorUnique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosisMycolic acids: structure, biosynthesis and physiological functionsUse of genomics and combinatorial chemistry in the development of new antimycobacterial drugsSynthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosisHypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteinsMorphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosisThe role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosisA point mutation in the mma3 gene is responsible for impaired methoxymycolic acid production in Mycobacterium bovis BCG strains obtained after 1927A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosisImmune Modulation as an Effective Adjunct Post-exposure Therapeutic for B. pseudomalleiCell wall structure of a mutant of Mycobacterium smegmatis defective in the biosynthesis of mycolic acids.Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitorsDiscovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents.Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.In vitro-in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis.The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis.Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensisMechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomalleiIsothermal amplification and molecular typing of the obligate intracellular pathogen Mycobacterium leprae isolated from tissues of unknown origins.Discovery of anti-TB agents that target the cell-division protein FtsZ.A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junín hemorrhagic fever arenavirus.Benzimidazole-based antibacterial agents against Francisella tularensis.MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein.Iterative feature removal yields highly discriminative pathwaysSubstituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei.Use of protein microarrays to define the humoral immune response in leprosy patients and identification of disease-state-specific antigenic profiles.Adeno-associated virus gene therapy vector scAAVIGF-I for transduction of equine articular chondrocytes and RNA-seq analysis.Identification of the apparent carrier in mycolic acid synthesis.Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis.Anomaly Detection in Host Signaling Pathways for the Early Prognosis of Acute Infection.Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model.Transient In Vivo Resistance Mechanisms of Burkholderia pseudomallei to Ceftazidime and Molecular Markers for Monitoring Treatment Response.The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection.Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Richard Slayden
@ast
Richard Slayden
@en
Richard Slayden
@es
Richard Slayden
@nl
Richard Slayden
@sl
type
label
Richard Slayden
@ast
Richard Slayden
@en
Richard Slayden
@es
Richard Slayden
@nl
Richard Slayden
@sl
prefLabel
Richard Slayden
@ast
Richard Slayden
@en
Richard Slayden
@es
Richard Slayden
@nl
Richard Slayden
@sl
P1053
O-8626-2016
P106
P21
P31
P3829
P496
0000-0001-6857-7277