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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

http://www.wikidata.org/entity/Q27684364

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Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Molecular and Cellular Mechanisms of Myelodysplastic Syndrome: Implications on Targeted Therapy The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets Epigenetic regulators and their impact on therapy in acute myeloid leukemia Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics An Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of Cholangiocarcinoma Dysregulated metabolism contributes to oncogenesis Increased Oxidative Stress as a Selective Anticancer Therapy Volasertib for AML: clinical use and patient consideration Next-generation sequencing to guide cancer therapy Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia Connections between TET proteins and aberrant DNA modification in cancer Concise review: Leukemia stem cells in personalized medicine IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma The next steps in next-gen sequencing of cancer genomes Isocitrate dehydrogenase mutations: new opportunities for translational research Cholangiocarcinoma Novel therapeutic targets of tumor metabolism Nutrient-sensing pathways and metabolic regulation in stem cells Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution The Sensitive Balance between the Fully Folded and Locally Unfolded Conformations of a Model Peroxiredoxin Next generation sequencing of acute myeloid leukemia: influencing prognosis.IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.New IDH1 mutant inhibitors for treatment of acute myeloid leukemia IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives 'Acute myeloid leukemia: a comprehensive review and 2016 update'Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer Emerging concepts of epigenetic dysregulation in hematological malignancies Epigenetics in Cancer: A Hematological Perspective Metabolic consequences of oncogenic IDH mutations Oncometabolites: tailoring our genes 2-Hydoxyglutarate: D/Riving Pathology in gLiomaS Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms NCI-60 Cell Line Screening: A Radical Departure in its Time.Molecular and Cellular Therapies: New challenges and opportunities.In vivo detection of 2-hydroxyglutarate in brain tumors by optimized point-resolved spectroscopy (PRESS) at 7T.Targeting tumor suppressor networks for cancer therapeutics.Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate.

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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

http://www.wikidata.org/entity/Q27684364

description

2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013 թվականի մայիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年论文

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name

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

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type

label

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

@ast

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

@en

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

@nl

prefLabel

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

@ast

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

@en

Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

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Byron DeLaBarre

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Camelia Gliser

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David P Schenkein

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Elena Mylonas

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Erica Hansen

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Erin Artin

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Fang Wang

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Francesco G Salituro

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Hua Yang

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P2860

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood

Structural studies ofSaccharomyces cerevesiaemitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction

Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Structure validation by Calpha geometry: phi,psi and Cbeta deviation

Overview of the CCP4 suite and current developments

Features and development of Coot

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Stéphane de Botton

Virginie Penard-Lacronique

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