A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods
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Towards the computational design of protein post-translational regulationProbing the activity modification space of the cysteine peptidase cathepsin K with novel allosteric modifiersIntegrated analysis of residue coevolution and protein structures capture key protein sectors in HIV-1 proteinsNMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38γEntropy Transfer between Residue Pairs and Allostery in Proteins: Quantifying Allosteric Communication in UbiquitinEvolutionary Covariance Combined with Molecular Dynamics Predicts a Framework for Allostery in the MutS DNA Mismatch Repair Protein.Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges.Computational investigation of conformational variability and allostery in cathepsin K and other related peptidases.Cathepsin K osteoporosis trials, pycnodysostosis and mouse deficiency models: Commonalities and differences.A combination of mutational and computational scanning guides the design of an artificial ligand-binding controlled lipase.Calpain research for drug discovery: challenges and potential.HIV Protease Inhibitor-Induced Cathepsin Modulation Alters Antigen Processing and Cross-PresentationOrigins of coevolution between residues distant in protein 3D structures.Cysteine cathepsin activity regulation by glycosaminoglycans.Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor.A Random Forest Model for Predicting Allosteric and Functional Sites on Proteins.An evolution-based strategy for engineering allosteric regulation.An allosteric site enables fine-tuning of cathepsin K by diverse effectors.Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L.Advances in the discovery of cathepsin K inhibitors on bone resorption.Co-evolution networks of HIV/HCV are modular with direct association to structure and function
P2860
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P2860
A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods
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2014 nî lūn-bûn
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2014 թուականին հրատարակուած գիտական յօդուած
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2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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name
A novel allosteric mechanism i ...... vered by computational methods
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A novel allosteric mechanism i ...... vered by computational methods
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A novel allosteric mechanism i ...... vered by computational methods
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type
label
A novel allosteric mechanism i ...... vered by computational methods
@ast
A novel allosteric mechanism i ...... vered by computational methods
@en
A novel allosteric mechanism i ...... vered by computational methods
@nl
prefLabel
A novel allosteric mechanism i ...... vered by computational methods
@ast
A novel allosteric mechanism i ...... vered by computational methods
@en
A novel allosteric mechanism i ...... vered by computational methods
@nl
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A novel allosteric mechanism i ...... vered by computational methods
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P2093
Matevž Korenč
Rama Ranganathan
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10.1038/NCOMMS4287
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P577
2014-01-01T00:00:00Z
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1028452754