Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase
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Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolismHuman 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormonesWhy boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiationCrystal structure of CHO reductase, a member of the aldo-keto reductase superfamilyStructure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolutionStructure of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzymeCrystal Structure of Human Liver 4-3-Ketosteroid 5 -Reductase (AKR1D1) and Implications for Substrate Binding and CatalysisStructure and catalytic mechanism of human steroid 5β-reductase (AKR1D1)Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase ( Hed KR): Molecular Basis of Stereo- and RegiospecificitiesConversion of Human Steroid 5 -Reductase (AKR1D1) into 3 -Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERINGCrystal structures of two tropinone reductases: different reaction stereospecificities in the same protein foldConversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestinsA cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13Fjord-region benzo[g]chrysene-11,12-dihydrodiol and benzo[c]phenanthrene-3,4-dihydrodiol as substrates for rat liver dihydrodiol dehydrogenase (AKR1C9): structural basis for stereochemical preferenceA vertebrate aldo-keto reductase active with retinoids and ethanol.Effect of dihydrotestosterone on mouse embryonic stem cells exposed to H2O2-induced oxidative stressMetabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamilySteroid hormone transforming aldo-keto reductases and cancer.Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms.Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1)Structural importance of the C-terminal region in pig aldo-keto reductase family 1 member C1 and their effects on enzymatic activity.Aldo-keto reductase (AKR) superfamily: genomics and annotation.Crystallization and preliminary X-ray diffraction analysis of mouse prostaglandin F2α synthase, AKR1B3.Promiscuity and diversity in 3-ketosteroid reductases.Aldo-keto reductases and formation of polycyclic aromatic hydrocarbon o-quinones.The three-dimensional structure of Clostridium absonum 7α-hydroxysteroid dehydrogenase: new insights into the conserved arginines for NADP(H) recognition.Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens.The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell deathEffects of Fungicides on Rat's Neurosteroid Synthetic Enzymes.ABS-Scan: In silico alanine scanning mutagenesis for binding site residues in protein-ligand complex.Crystallization and preliminary X-ray analysis of the complex of NADH and 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831.Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.Kinetic alteration of a human dihydrodiol/3alpha-hydroxysteroid dehydrogenase isoenzyme, AKR1C4, by replacement of histidine-216 with tyrosine or phenylalanine.Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimaeric enzymes.Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA.Aldo-keto reductases in which the conserved catalytic histidine is substitutedCharacterization of homogeneous recombinant rat ovarian 20alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile.Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen.
P2860
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P2860
Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Steroid recognition and regula ...... roid/dihydrodiol dehydrogenase
@ast
Steroid recognition and regula ...... roid/dihydrodiol dehydrogenase
@en
Steroid recognition and regula ...... roid/dihydrodiol dehydrogenase
@nl
type
label
Steroid recognition and regula ...... roid/dihydrodiol dehydrogenase
@ast
Steroid recognition and regula ...... roid/dihydrodiol dehydrogenase
@en
Steroid recognition and regula ...... roid/dihydrodiol dehydrogenase
@nl
prefLabel
Steroid recognition and regula ...... roid/dihydrodiol dehydrogenase
@ast
Steroid recognition and regula ...... roid/dihydrodiol dehydrogenase
@en
Steroid recognition and regula ...... roid/dihydrodiol dehydrogenase
@nl
P2093
P1433
P1476
Steroid recognition and regula ...... roid/dihydrodiol dehydrogenase
@en
P2093
P304
P356
10.1016/S0969-2126(97)00234-7
P577
1997-06-01T00:00:00Z