The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity
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Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humansThe structure of human 5-lipoxygenaseInverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epitheliaA 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expressionCoactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 productionGrowing with dinosaurs: natural products from the Cretaceous relict Metasequoia glyptostroboides Hu & Cheng—a molecular reservoir from the ancient world with potential in modern medicineStructural basis of carotenoid cleavage: from bacteria to mammalsThe 1.85 Å Structure of an 8 R -Lipoxygenase Suggests a General Model for Lipoxygenase Product SpecificityA Covalent Linker Allows for Membrane Targeting of an Oxylipin Biosynthetic Complex † ‡Structural Insights into Maize Viviparous14, a Key Enzyme in the Biosynthesis of the Phytohormone Abscisic AcidStructure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+ RegulationCrystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysisRole of arachidonic acid lipoxygenase metabolites in the regulation of vascular toneMammalian lipoxygenases and their biological relevanceChemistry of the retinoid (visual) cyclePositional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymesProbing a novel potato lipoxygenase with dual positional specificity reveals primary determinants of substrate binding and requirements for a surface hydrophobic loop and has implications for the role of lipoxygenases in tubersSequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesisThe future of crystallography in drug discovery.Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoformsX-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solutionThe structural basis for specificity in lipoxygenase catalysis.Molecular dynamics simulation of mammalian 15S-lipoxygenase with AMBER force field.Crystal structures of vegetative soybean lipoxygenase VLX-B and VLX-D, and comparisons with seed isoforms LOX-1 and LOX-3The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding.The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation.The N-terminal beta-barrel structure of lipid body lipoxygenase mediates its binding to liposomes and lipid bodies.Safeguarding Structural Data Repositories against Bad ApplesCrystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase.Avoidable errors in deposited macromolecular structures: an impediment to efficient data mining.Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes.Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegenerationStructural basis for lipoxygenase specificity. Conversion of the human leukocyte 5-lipoxygenase to a 15-lipoxygenating enzyme species by site-directed mutagenesis.Mutagenesis and modelling of linoleate-binding to pea seed lipoxygenase.Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection.Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.5-Lipoxygenase and leukotrienes. Transgenic mouse and nuclear targeting studies.Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases
P2860
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P2860
The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
The structure of mammalian 15- ...... nants of substrate specificity
@ast
The structure of mammalian 15- ...... nants of substrate specificity
@en
The structure of mammalian 15- ...... nants of substrate specificity
@nl
type
label
The structure of mammalian 15- ...... nants of substrate specificity
@ast
The structure of mammalian 15- ...... nants of substrate specificity
@en
The structure of mammalian 15- ...... nants of substrate specificity
@nl
prefLabel
The structure of mammalian 15- ...... nants of substrate specificity
@ast
The structure of mammalian 15- ...... nants of substrate specificity
@en
The structure of mammalian 15- ...... nants of substrate specificity
@nl
P2093
P2860
P3181
P356
P1476
The structure of mammalian 15- ...... nants of substrate specificity
@en
P2093
A Villaseñor
M F Browner
R Fletterick
S A Gillmor
P2860
P304
P3181
P356
10.1038/NSB1297-1003
P577
1997-12-01T00:00:00Z