The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
about
3D models of MBP, a biologically active metabolite of bisphenol A, in human estrogen receptor α and estrogen receptor βMolecular determinants of the estrogen receptor-coactivator interfaceAIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptorCIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinantThe human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptorTernary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcriptionThe vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifsERAP140, a conserved tissue-specific nuclear receptor coactivator.CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptorSuppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptorFamilial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptorsThyroxine-thyroid hormone receptor interactionsA coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expressionNuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicingHuman ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocketMultiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activationZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylasesIdentification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptorThe molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptorPKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1DcpS as a therapeutic target for spinal muscular atrophy.DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcriptionRsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain.X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cellsA subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRAGaussian-weighted RMSD superposition of proteins: a structural comparison for flexible proteins and predicted protein structures.The modified human DNA repair enzyme O(6)-methylguanine-DNA methyltransferase is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damageElectrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifsAcetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBPThe xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CARThe orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptorsThe orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repressionDevelopment of a second-generation antiandrogen for treatment of advanced prostate cancerThe p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficaciesThe structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformationEstradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and betaDifferential estradiol and selective estrogen receptor modulator (SERM) regulation of Keratin 13 gene expression and its underlying mechanism in breast cancer cellsSelective androgen receptor modulators in preclinical and clinical developmentN-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif
P2860
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P2860
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
The structural basis of estrog ...... this interaction by tamoxifen
@ast
The structural basis of estrog ...... this interaction by tamoxifen
@en
The structural basis of estrog ...... this interaction by tamoxifen
@nl
type
label
The structural basis of estrog ...... this interaction by tamoxifen
@ast
The structural basis of estrog ...... this interaction by tamoxifen
@en
The structural basis of estrog ...... this interaction by tamoxifen
@nl
prefLabel
The structural basis of estrog ...... this interaction by tamoxifen
@ast
The structural basis of estrog ...... this interaction by tamoxifen
@en
The structural basis of estrog ...... this interaction by tamoxifen
@nl
P2093
P3181
P1433
P1476
The structural basis of estrog ...... this interaction by tamoxifen
@en
P2093
G L Greene
P J Kushner
P304
P3181
P356
10.1016/S0092-8674(00)81717-1
P407
P577
1998-12-23T00:00:00Z