Crystal structure of the E166A mutant of extended-spectrum beta-lactamase Toho-1 at 1.8 A resolution
about
Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threatAcyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillinThe Acylation Mechanism of CTX-M β-Lactamase at 0.88 Å ResolutionImprovement of crystal quality by surface mutations of β-lactamase Toho-1An Antibiotic-Resistance Enzyme from a Deep-Sea BacteriumThe active site protonation states of perdeuterated Toho-1 β-lactamase determined by neutron diffraction support a role for Glu166 as the general base in acylationNeutron and X-ray Crystal Structures of a Perdeuterated Enzyme Inhibitor Complex Reveal the Catalytic Proton Network of the Toho-1 -Lactamase for the Acylation ReactionStructural insights into the broadened substrate profile of the extended-spectrum β-lactamase OXY-1-1 from Klebsiella oxytocaTargeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid DerivativeCrystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibioticsA novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in BrazilEnhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.A new SHV-derived extended-spectrum beta-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the -loop.A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil.Novel cefotaximase (CTX-M-16) with increased catalytic efficiency due to substitution Asp-240-->Gly.CTX-M-type extended-spectrum beta-lactamase that hydrolyzes ceftazidime through a single amino acid substitution in the omega loopIdentification of a chromosome-borne expanded-spectrum class a beta-lactamase from Erwinia persicinaBiochemical-genetic analysis and distribution of DES-1, an Ambler class A extended-spectrum beta-lactamase from Desulfovibrio desulfuricans.Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases.Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatmentIdentification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry.CTX-M-93, a CTX-M variant lacking penicillin hydrolytic activityMolecular basis for the catalytic specificity of the CTX-M extended-spectrum β-lactamases.Growing group of extended-spectrum beta-lactamases: the CTX-M enzymesCefotaximases (CTX-M-ases), an expanding family of extended-spectrum beta-lactamases.The continuing challenge of ESBLs.Comparative Characterization of CTX-M-64 and CTX-M-14 Provides Insights into the Structure and Catalytic Activity of the CTX-M Class of Enzymes.Active-Site Protonation States in an Acyl-Enzyme Intermediate of a Class A β-Lactamase with a Monobactam SubstrateRole of a mutation at position 167 of CTX-M-19 in ceftazidime hydrolysis.Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis.Designing of inhibitors against CTX-M-15 type β-lactamase: potential drug candidate against β-lactamases-producing multi-drug-resistant bacteria.Nucleotide sequence and characterization of a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-10) isolated in Spain.Characterization of a chromosomally encoded extended-spectrum class A beta-lactamase from Kluyvera cryocrescens.CTX-M-1, CTX-M-3, and CTX-M-14 beta-lactamases from Enterobacteriaceae isolated in FranceColE1-like plasmid pIP843 of Klebsiella pneumoniae encoding extended-spectrum beta-lactamase CTX-M-17.Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1.The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon AcylationAnalysis of the bla(toho) gene coding for Toho-2-beta-lactamaseEffects of Ser130Gly and Asp240Lys substitutions in extended-spectrum beta-lactamase CTX-M-9.pKa, MM, and QM studies of mechanisms of beta-lactamases and penicillin-binding proteins: acylation step.
P2860
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P2860
Crystal structure of the E166A mutant of extended-spectrum beta-lactamase Toho-1 at 1.8 A resolution
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Crystal structure of the E166A ...... ase Toho-1 at 1.8 A resolution
@ast
Crystal structure of the E166A ...... ase Toho-1 at 1.8 A resolution
@en
Crystal structure of the E166A ...... ase Toho-1 at 1.8 A resolution
@nl
type
label
Crystal structure of the E166A ...... ase Toho-1 at 1.8 A resolution
@ast
Crystal structure of the E166A ...... ase Toho-1 at 1.8 A resolution
@en
Crystal structure of the E166A ...... ase Toho-1 at 1.8 A resolution
@nl
prefLabel
Crystal structure of the E166A ...... ase Toho-1 at 1.8 A resolution
@ast
Crystal structure of the E166A ...... ase Toho-1 at 1.8 A resolution
@en
Crystal structure of the E166A ...... ase Toho-1 at 1.8 A resolution
@nl
P2093
P356
P1476
Crystal structure of the E166A ...... ase Toho-1 at 1.8 A resolution
@en
P2093
Ishiguro M
Matsuzawa H
Yamaguchi K
P304
P356
10.1006/JMBI.1998.2432
P407
P577
1999-02-01T00:00:00Z