Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
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Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and SchistosomiasisDiscovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate DehydrogenaseNovel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screeningScreening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes.Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp3)-H Arylation.Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei.Drug discovery: Chemical diversity targets malaria.Divergent Synthesis of Cyclopropane-Containing Lead-Like Compounds, Fragments and Building Blocks through a Cobalt Catalyzed Cyclopropanation of Phenyl Vinyl SulfideDiversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes.Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates.Gold-Catalyzed Asymmetric Intramolecular Cyclization of N-Allenamides for the Synthesis of Chiral Tetrahydrocarbolines.A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi.Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.Identification of Hsp90 inhibitors with anti-Plasmodium activity.A Stereoselective [3+1] Ring Expansion for the Synthesis of Highly Substituted Methylene Azetidines.Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.Drugs in Development for Malaria.MalariaRecent updates in the discovery and development of novel antimalarial drug candidatesRing Expansion of Bicyclic Methyleneaziridines via Concerted, Near-Barrierless [2,3]-Stevens Rearrangements of Aziridinium YlidesSynthesis and Study of the Antimalarial Cardamom PeroxideRecent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment CollectionsA Brief Overview of Two Major Strategies in Diversity-Oriented Synthesis: Build/Couple/Pair and Ring-DistortionSamarium(II) folding cascades involving hydrogen atom transfer for the synthesis of complex polycycles
P2860
Q28553109-A00A64B6-BDD1-4583-A8ED-28FB443F1603Q30041606-31646E2C-08D5-4ADC-9C00-585F65C932B0Q33560788-1B04226E-A45B-4962-A026-88839FD487BDQ38695331-EA3F4999-8254-4ED8-8A6D-21AF85C82D8FQ38735109-5A96142C-4647-4D1C-9024-FA6775B82833Q38953573-16122E8A-3157-4BE8-AE33-981B1ACA9715Q39003990-D7D86AAB-BD5F-4C7A-88D2-128BE05492E1Q40106428-C2FB8E01-62D6-44E9-88CF-07E073AB86BFQ40124799-91F2175D-EC76-457E-A551-0FB5AF77DBF0Q40139788-7FB9B865-74C6-4058-A1E4-65959352B456Q40388869-08DE12D9-30CF-4CFB-BA44-67139F0E86FEQ40499672-8256DE7C-63DA-476C-8804-96AD917DE0A1Q42359652-6DE13A9A-A349-4F25-80A7-2391742B05C1Q42367278-643B34CB-13F3-4FE7-90A6-FEB770177328Q43434845-1DDCC347-B6D7-4E10-8A30-1FFCA291AC1DQ47401675-0915D4C3-3A37-41B5-AF47-C5AA19CA8006Q48018710-5ACBFB48-4DD0-40F5-A22D-7268B8B7BD00Q48021791-5C5A0142-1D00-48AC-B6B9-C43B47A74A32Q48022253-91A09EA7-6A27-43FD-8344-B0414B9D52E1Q48188812-0475C8A3-FCC5-4B9C-BFE4-7929514DCF94Q49927350-D13EADC8-F35A-46B4-B374-CD8F9749022BQ55278895-35999975-64A1-453D-A90E-5B8607168AD4Q56378965-AE9959FE-8299-456F-AE72-ACB5B00544C2Q56403247-6843F8AB-FCE5-40BA-8CAA-13C8D8D50B44Q57192280-531C5BAB-26F8-45AA-9774-4CA2BC7A69ACQ57496665-9C61CDEE-25E4-4869-AA4F-F7E96EA81EF0Q58553557-0942D99E-BA96-4099-A029-03657D41A841Q58580325-E7A7CED8-E76D-4750-B274-FD61615F9419Q59136666-F2C76867-BCA4-4CF1-9BAA-F14016CFD2F6
P2860
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
description
2016 nî lūn-bûn
@nan
2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
@ast
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
@en
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
@nl
type
label
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
@ast
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
@en
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
@nl
prefLabel
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
@ast
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
@en
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
@en
P2093
Amit Sharma
Benito Munoz
Bennett C Meier
Branko Mitasev
Christina A Scherer
Clemens H M Kocken
David Clarke
Eamon Comer
Eli L Moss
Emily Lund
P2860
P2888
P304
P3181
P356
10.1038/NATURE19804
P407
P50
P577
2016-09-07T00:00:00Z
P6179
1032780495