GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. - Test2 - elhamkhani - TriplyDB

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

http://www.wikidata.org/entity/Q27865189

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Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1 Metabolomics applied to the pancreatic islet Potential roles of GPR120 and its agonists in the management of diabetes Interplay between lipids and branched-chain amino acids in development of insulin resistance Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1 Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents Variants in the FFAR1 gene are associated with beta cell function.Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms.Glucolipotoxicity of the pancreatic beta cell.Increased glucose metabolism and glycerolipid formation by fatty acids and GPR40 receptor signaling underlies the fatty acid potentiation of insulin secretion Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity.Lipid receptors and islet function: therapeutic implications?Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion.Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass.Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice.Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity.GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo Perilipin 5 regulates islet lipid metabolism and insulin secretion in a cAMP-dependent manner: implication of its role in the postprandial insulin secretion.The intestinal microbiome and skeletal fitness: Connecting bugs and bones Emerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet beta-cell.G protein-coupled receptors and insulin secretion: 119 and counting Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases.PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin.The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation.Gustducin couples fatty acid receptors to GLP-1 release in colon.Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.Glucolipotoxicity: fuel excess and beta-cell dysfunction.

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P2860

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

http://www.wikidata.org/entity/Q27865189

description

2007 nî lūn-bûn

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2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2007 թվականի ապրիլին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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GPR40 is necessary but not suf ...... of insulin secretion in vivo.

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Caroline Tremblay

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Daniel C-H Lin

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Elizabeth Oseid

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Jian Luo

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Martin G Latour

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Thomas L Jetton

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P2860

Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function.

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.

A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release.

Role of GPR40 in fatty acid action on the beta cell line INS-1E.

Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

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1087-1094

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scholarly article

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1627058

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10.2337/DB06-1532

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4

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56

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Thierry Alquier

Vincent Poitout

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2007-04-01T00:00:00Z

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51379085

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17395749

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Free fatty acid receptor 1

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1853382

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