Nej1 recruits the Srs2 helicase to DNA double-strand breaks and supports repair by a single-strand annealing-like mechanism.
about
Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repairThe hidden side of unstable DNA repeats: Mutagenesis at a distanceYeast Nej1 is a key participant in the initial end binding and final ligation steps of nonhomologous end joining.Srs2: the "Odd-Job Man" in DNA repair.Regulation of homologous recombination in eukaryotes.The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining.Pro-recombination Role of Srs2 Protein Requires SUMO (Small Ubiquitin-like Modifier) but Is Independent of PCNA (Proliferating Cell Nuclear Antigen) Interaction.Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing.Regulation of recombination and genomic maintenance.Regulation of non-homologous end joining via post-translational modifications of components of the ligation step.BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.Tight Regulation of Srs2 Helicase Activity Is Crucial for Proper Functioning of DNA Repair Mechanisms.The Main Role of Srs2 in DNA Repair Depends on Its Helicase Activity, Rather than on Its Interactions with PCNA or Rad51
P2860
Q21144986-41669626-6B18-452E-8223-BD28486A23D3Q27027501-BB1008B3-A5BE-412B-9A3E-2B03FE1545CAQ27933248-9F521AB7-E186-47F1-87C8-6283D8880C95Q33754225-E26FF974-C7CB-417E-83C9-F98F36A16A6DQ33966065-5B8FD0CD-0643-4699-804A-76D612767C48Q34004894-F1EEC199-8395-4195-BB94-0E1863D89F0DQ36755067-EA39DA6C-C842-4218-9976-03F450489DE3Q37606893-2C1B4EE5-6E2B-4B29-B907-95E21FF86979Q38559892-5CC7D2EC-CA58-4B0C-9BA7-BA893C87A203Q39028618-63E35E95-4948-41F4-8EAB-1AA87BD2A870Q52617694-D1610818-90A0-45D6-B917-2154F21FFC7EQ52727056-2BAA4D80-D046-4C06-AA7A-725EA25D6383Q57753635-886B6E04-FA0F-4F24-81A1-00F571D2AA48
P2860
Nej1 recruits the Srs2 helicase to DNA double-strand breaks and supports repair by a single-strand annealing-like mechanism.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Nej1 recruits the Srs2 helicas ...... rand annealing-like mechanism.
@ast
Nej1 recruits the Srs2 helicas ...... rand annealing-like mechanism.
@en
Nej1 recruits the Srs2 helicas ...... rand annealing-like mechanism.
@nl
type
label
Nej1 recruits the Srs2 helicas ...... rand annealing-like mechanism.
@ast
Nej1 recruits the Srs2 helicas ...... rand annealing-like mechanism.
@en
Nej1 recruits the Srs2 helicas ...... rand annealing-like mechanism.
@nl
prefLabel
Nej1 recruits the Srs2 helicas ...... rand annealing-like mechanism.
@ast
Nej1 recruits the Srs2 helicas ...... rand annealing-like mechanism.
@en
Nej1 recruits the Srs2 helicas ...... rand annealing-like mechanism.
@nl
P2093
P2860
P356
P1476
Nej1 recruits the Srs2 helicas ...... trand annealing-like mechanism
@en
P2093
Dana Vigasová
Jiang Chen
Miroslav Chovanec
Sidney D Carter
P2860
P304
12037-12042
P356
10.1073/PNAS.0903869106
P407
P577
2009-07-01T00:00:00Z