The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.
about
Functional wiring of the yeast kinome revealed by global analysis of genetic network motifsDNA damage signalling prevents deleterious telomere addition at DNA breaksImplication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage responseSystematic quantification of gene interactions by phenotypic array analysisDNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.Antimutator variants of DNA polymerasesThe protein kinase Snf1 is required for tolerance to the ribonucleotide reductase inhibitor hydroxyureaInhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme.Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Small Subunit Localization in Response to Iron Deficiency.Nej1 recruits the Srs2 helicase to DNA double-strand breaks and supports repair by a single-strand annealing-like mechanism.Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae.A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae.Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmanninNuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levelsSubcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathwaysTOR signaling is a determinant of cell survival in response to DNA damage.UV induced ubiquitination of the yeast Rad4-Rad23 complex promotes survival by regulating cellular dNTP pools.Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes.Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance.Genetic instability in budding and fission yeast-sources and mechanismsLimiting amounts of budding yeast Rad53 S-phase checkpoint activity results in increased resistance to DNA alkylation damageIxr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP poolsAssessment of the biological pathways targeted by isocyanate using N-succinimidyl N-methylcarbamate in budding yeast Saccharomyces cerevisiaeThe yeast DNA damage checkpoint proteins control a cytoplasmic response to DNA damageThe subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence.Identification of phosphorylation sites on the yeast ribonucleotide reductase inhibitor Sml1.On the detection of functionally coherent groups of protein domains with an extension to protein annotation.Excess single-stranded DNA inhibits meiotic double-strand break repair.Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunitA truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae.A proteome-wide analysis of kinase-substrate network in the DNA damage response.Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae.Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutantsBreak-induced replication is highly inaccurateColocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damageRecombinational repair and restart of damaged replication forks.
P2860
Q24606805-5BEB6957-C5EA-4913-84B5-8D2082EC0978Q24646336-92194A6B-FFE8-485E-B6F4-4013E810B802Q24650185-C63564A5-A8A9-430F-B1D7-EE3A41AFBFF8Q24805253-D6FBC288-6115-44DF-B9F2-7174AFD06CEDQ24815044-8D91606B-1657-4255-BA59-5FF1A930235EQ27024636-17E145EA-A229-4FA8-94D3-B659E345F551Q27929838-82EA35B3-5102-44D5-BF7A-4D4F4CDB5839Q27930202-99665AE1-332D-4BA8-8F7A-0183ABE2ACE8Q27930928-09EA836D-66B4-4B53-8F94-B7D47F224087Q27931948-E4053135-671B-4746-BD84-6A9655B5C834Q27932046-024E7FB9-09C9-4CC2-A49D-EB682D739501Q27932089-A13F4F4B-AA00-443A-8361-B18AD851E6AEQ27932610-E2B2898F-C954-4012-929E-B00F3ADB83DDQ27933104-6EF64CF0-B9FC-43DE-A46A-E5537911B174Q27933133-0F0AF169-1B03-4CEF-820E-E29D2F6D81D4Q27933722-F12D9362-7D51-4132-9A60-86D9CCF9BF3EQ27933989-E60D3FFE-E01B-4305-95AD-63CAA4EA60FBQ27936718-AC2DB074-9B40-4497-B3AD-FBFB31BD8193Q27937332-B26253AD-97E6-47C3-AF31-5742C9A5D9BFQ27938358-D7BB9A29-59A9-48EA-9D85-9AEAE6D3EF26Q27938725-13B169A8-E77B-4AB9-92AA-9AD019353967Q27939432-363427C5-D310-4C9F-B412-F8198B175FA5Q27939559-331426E3-2B56-4972-B2F5-63A507EA8A98Q28264035-8E36B79A-297A-4A21-A862-8E72A1FCE435Q28391868-8D9C0C0E-81C5-40E7-9BE5-86A1AEE3ADE5Q28478063-1D0B5477-DA02-4040-8E84-D39D13627B41Q28541434-76C6EA88-954A-4DE3-A58C-665ED671EAAAQ30479667-1949F9EB-834F-4966-BAB1-CAB299CD17ABQ30596955-DC227F31-70C7-4C86-AC33-0A3336A7703DQ31033545-99BF9A98-EDE1-4BE3-ADCD-132AD9E305ECQ33302712-01DE2DEF-B736-4E3D-BEC1-E9FAF4FBA960Q33310471-C05BC541-7C80-4AA4-B927-DB6BE2DF45C8Q33374228-36B287FB-F4E3-405E-8190-93012603F06CQ33522877-DAFB8D74-3C2E-4D28-8662-E7A2FCCE336FQ33535179-DA179F0D-5A4D-4DF1-A987-7932CF01478CQ33611684-E9C16D04-2F18-4CC5-A6AF-8FCFFA25B3E4Q33700062-E63994EB-77B7-46DB-8637-CCA6A8BF7267Q33828325-1F812C03-221A-469C-B95C-6EB851AE0A98Q33888520-7F3F5E34-D58C-45AE-AC32-300F2BF325D6Q33962242-B1FD7F3C-A1B6-4D48-9C49-F4CE9EAE6815
P2860
The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
The Dun1 checkpoint kinase pho ...... tide reductase inhibitor Sml1.
@ast
The Dun1 checkpoint kinase pho ...... tide reductase inhibitor Sml1.
@en
The Dun1 checkpoint kinase pho ...... tide reductase inhibitor Sml1.
@nl
type
label
The Dun1 checkpoint kinase pho ...... tide reductase inhibitor Sml1.
@ast
The Dun1 checkpoint kinase pho ...... tide reductase inhibitor Sml1.
@en
The Dun1 checkpoint kinase pho ...... tide reductase inhibitor Sml1.
@nl
prefLabel
The Dun1 checkpoint kinase pho ...... tide reductase inhibitor Sml1.
@ast
The Dun1 checkpoint kinase pho ...... tide reductase inhibitor Sml1.
@en
The Dun1 checkpoint kinase pho ...... tide reductase inhibitor Sml1.
@nl
P2860
P3181
P356
P1476
The Dun1 checkpoint kinase pho ...... tide reductase inhibitor Sml1.
@en
P2093
Xiaolan Zhao
P2860
P304
P3181
P356
10.1073/PNAS.062502299
P407
P577
2002-03-19T00:00:00Z