Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1
about
Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6The N-end rule pathwayHECT and RING finger families of E3 ubiquitin ligases at a glanceMetazoan Hsp70-based protein disaggregases: emergence and mechanismsDNAJs: more than substrate delivery to HSPASelective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradationMolecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradationQuality control and fate determination of Hsp90 client proteinsProtein homeostasis at the plasma membraneProtein quality control in the nucleusPhenotypes on demand via switchable target protein degradation in multicellular organisms.Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation.Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins.Prefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility.Hsp70 nucleotide exchange factor Fes1 is essential for ubiquitin-dependent degradation of misfolded cytosolic proteins.The yeast ubr1 ubiquitin ligase participates in a prominent pathway that targets cytosolic thermosensitive mutants for degradationCdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.Degradation-mediated protein quality control at the inner nuclear membraneA chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stabilityThe role of AhR in autoimmune regulation and its potential as a therapeutic target against CD4 T cell mediated inflammatory disorderRibosomal proteins produced in excess are degraded by the ubiquitin-proteasome systemArtificial targeting of misfolded cytosolic proteins to endoplasmic reticulum as a mechanism for clearance.The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor TurnoverDeubiquitinating enzymes Ubp2 and Ubp15 regulate endocytosis by limiting ubiquitination and degradation of ARTsHierarchical functional specificity of cytosolic heat shock protein 70 (Hsp70) nucleotide exchange factors in yeast.Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone systemNormal levels of the antiprion proteins Btn2 and Cur1 cure most newly formed [URE3] prion variantsA nucleus-based quality control mechanism for cytosolic proteinsUbiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndromeIdentification of mammalian protein quality control factors by high-throughput cellular imagingThe N-end rule pathway and regulation by proteolysisCellular strategies of protein quality control.How the nucleus copes with proteotoxic stress.Quality control for unfolded proteins at the plasma membrane.Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat StressThe Type II Hsp40 Sis1 cooperates with Hsp70 and the E3 ligase Ubr1 to promote degradation of terminally misfolded cytosolic protein.Nuclear protein quality is regulated by the ubiquitin-proteasome system through the activity of Ubc4 and San1 in fission yeast.Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteinsExposed hydrophobicity is a key determinant of nuclear quality control degradation.Protein targeting and degradation are coupled for elimination of mislocalized proteins.
P2860
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P2860
Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Cytoplasmic protein quality co ...... biquitin ligases Ubr1 and San1
@ast
Cytoplasmic protein quality co ...... biquitin ligases Ubr1 and San1
@en
Cytoplasmic protein quality co ...... iquitin ligases Ubr1 and San1.
@nl
type
label
Cytoplasmic protein quality co ...... biquitin ligases Ubr1 and San1
@ast
Cytoplasmic protein quality co ...... biquitin ligases Ubr1 and San1
@en
Cytoplasmic protein quality co ...... iquitin ligases Ubr1 and San1.
@nl
prefLabel
Cytoplasmic protein quality co ...... biquitin ligases Ubr1 and San1
@ast
Cytoplasmic protein quality co ...... biquitin ligases Ubr1 and San1
@en
Cytoplasmic protein quality co ...... iquitin ligases Ubr1 and San1.
@nl
P2093
P2860
P921
P3181
P356
P1476
Cytoplasmic protein quality co ...... biquitin ligases Ubr1 and San1
@en
P2093
Jarrod W Heck
Randolph Y Hampton
Samantha K Cheung
P2860
P304
P3181
P356
10.1073/PNAS.0910591107
P407
P577
2010-01-19T00:00:00Z