Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
about
Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complexTargeting p97 to Disrupt Protein Homeostasis in CancerRing of Change: CDC48/p97 Drives Protein Dynamics at ChromatinRibosome-based quality control of mRNA and nascent peptidesRibosome-associated protein quality controlThe 26S proteasome is a multifaceted target for anti-cancer therapiesDNAJs: more than substrate delivery to HSPAProtein quality control systems associated with no-go and nonstop mRNA surveillance in yeast.Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation.Perilous journey: a tour of the ubiquitin-proteasome systemStructural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated DegradationListerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociationRibosomal proteins produced in excess are degraded by the ubiquitin-proteasome systemInitiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome UbiquitinationAsc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation.The ribosome-bound quality control complex remains associated to aberrant peptides during their proteasomal targeting and interacts with Tom1 to limit protein aggregationA Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factorsProfiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis.Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex.Granulostasis: Protein Quality Control of RNP Granules.Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing.Structure and assembly pathway of the ribosome quality control complex.Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.Ubiquitination of newly synthesized proteins at the ribosome.The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon.Regulation by a chaperone improves substrate selectivity during cotranslational protein targetingRkr1/Ltn1 Ubiquitin Ligase-mediated Degradation of Translationally Stalled Endoplasmic Reticulum Proteins.Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97Structure and function of the AAA+ ATPase p97/Cdc48p.Doa1 targets ubiquitinated substrates for mitochondria-associated degradation.Role of p97/VCP (Cdc48) in genome stability.A cotranslational ubiquitination pathway for quality control of misfolded proteins.Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligaseRqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits.Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunitsDistinct types of translation termination generate substrates for ribosome-associated quality control.Nuclear import factor Srp1 and its associated protein Sts1 couple ribosome-bound nascent polypeptides to proteasomes for cotranslational degradation.
P2860
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P2860
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
@ast
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
@en
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
@nl
type
label
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
@ast
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
@en
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
@nl
altLabel
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome
@en
prefLabel
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
@ast
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
@en
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
@nl
P2093
P2860
P3181
P356
P1433
P1476
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.
@en
P2093
Natalie J Kolawa
Rati Verma
Raymond J Deshaies
Robert S Oania
P2860
P304
P3181
P356
10.7554/ELIFE.00308
P407
P577
2013-01-22T00:00:00Z