Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
about
The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore †Structure-Based Design, Synthesis, and Evaluation of 2′-(2-Hydroxyethyl)-2′-deoxyadenosine and the 5′-Diphosphate Derivative as Ribonucleotide Reductase InhibitorsSite-Specific Incorporation of 3-Nitrotyrosine as a Probe of p K a Perturbation of Redox-Active Tyrosines in Ribonucleotide ReductaseEvaluating the Therapeutic Potential of a Non-Natural Nucleotide That Inhibits Human Ribonucleotide ReductaseRole of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide ReductaseTangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductaseInhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme.Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelityThymidine kinase 1 regulatory fine-tuning through tetramer formationThe origin and evolution of ribonucleotide reductionAutomated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: an analysis of ATP-induced ribonucleotide reductase R1 hexamerization data.Transgenic cardiac-targeted overexpression of human thymidylate kinaseThe structural basis for the allosteric regulation of ribonucleotide reductase.Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly.Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.Trans-species activity of a nonself recognition domain.The Crystal Structure of Thermotoga maritima Class III Ribonucleotide Reductase Lacks a Radical Cysteine Pre-Positioned in the Active SiteRole of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1Novel mutator mutants of E. coli nrdAB ribonucleotide reductase: insight into allosteric regulation and control of mutation ratesTargeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy.Class I ribonucleotide reductases: metallocofactor assembly and repair in vitro and in vivo.Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli.Identification of Non-nucleoside Human Ribonucleotide Reductase ModulatorsThe Promiscuity of Allosteric Regulation of Nuclear Receptors by Retinoid X ReceptorHypermutability and error catastrophe due to defects in ribonucleotide reductase.Inhibition of chlamydial class Ic ribonucleotide reductase by C-terminal peptides from protein R2.DNA building blocks: keeping control of manufacture.The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years.Nonself recognition through intermolecular disulfide bond formation of ribonucleotide reductase in neurosporaExpression Pattern Similarities Support the Prediction of Orthologs Retaining Common Functions after Gene Duplication Events.Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant.Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpointPhylogenetic sequence analysis and functional studies reveal compensatory amino acid substitutions in loop 2 of human ribonucleotide reductase.Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase.Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule.Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit.3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
P2860
Q27651067-89FD5C5B-90C1-4C6D-AEB2-AA1708213065Q27657014-7FDEC096-7411-41CD-A1D9-DF7014B9F699Q27662095-5BBB42CA-CD5A-4220-8D04-3808413B599CQ27671797-0BAC21CB-E05D-479C-8D2C-EBEC4D12B93EQ27678275-853C395B-C6F9-4C6B-BE5E-1900A9491432Q27681351-CA007F0B-5BBE-4192-81FA-4A2E90306FA7Q27930202-67E24CEE-3FD6-437A-8232-C41C1D74E372Q28542499-21FB8F71-F93A-4D0F-8813-22EBE13BD5B7Q28570313-36BBB87B-3E85-4E19-9579-E351869033D7Q28649971-29367325-C2D9-4C9B-BDF4-B349261E7834Q33517852-DD12DE24-CDEF-48B8-9073-17F74750B99DQ33690295-218110EB-AD2E-4E4D-A282-AE067EEB6C58Q33762296-23A5E0A6-E14C-4E44-B998-8495143BB6FBQ34424946-D238689C-5A1A-4AAB-B779-B17475F63DFAQ34609166-A54002C3-E5B1-4AFD-BDF0-CA7A597E5049Q34630831-32EED44F-6A82-48FC-8288-88B10277513AQ35683551-42CB2CED-E9E6-472B-8787-EDCBDC7E6453Q35844439-B87DE705-E050-48C3-8774-0ACAFDEA25EBQ35922997-79991723-071A-40B0-9FF8-25CBEE076630Q36353167-8B65759D-E70F-4ED4-92CA-1E2D85E4270BQ36435630-4283063A-570D-43DD-8D57-A1B59A40DA68Q36505984-3D42CC26-46D3-4C3B-8302-70E546FE549EQ36575539-51605F29-94B7-45EB-B193-F783D6F8D952Q37211543-26807C25-4BED-4745-81C1-7145975515FDQ37319784-CCE2F750-43E8-4FA4-B4D8-4AFC4281DA30Q37850086-197F6760-52F9-4ED6-A890-45FEB17F23F9Q37952292-81877530-D88F-418E-B8FA-DA6EE5DEC7E6Q38012192-9A550F93-0E83-4C3E-A31F-CA07022C2CF9Q39218469-C89A0E2E-CB53-456E-991A-287B3BF58F0AQ39682646-AF98823F-CE49-443A-845D-5C0EFB5EA271Q42568349-3252D38A-85D5-4AE2-9308-1D8AE027AF1AQ42738775-FE8FA164-5207-4241-B060-B0993A6544D0Q47952981-0C6AB610-764C-4924-8C17-DED1D174C1F3Q48099410-240003E4-709C-4F82-AABE-EAE75BB67113Q48112706-09FEF2E0-9AA1-4BBD-A0ED-AFF1DFA383A9Q48125298-DF14D3D3-BDAE-431A-946E-6C6C565D0C13Q49819835-8C6FABF0-7933-4952-912C-218CBF5E7156Q53070196-7B7D17E7-05EF-482F-8A3C-2E9A97937DF7
P2860
Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
@ast
Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
@en
Structures of eukaryotic ribon ...... insights into dNTP regulation.
@nl
type
label
Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
@ast
Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
@en
Structures of eukaryotic ribon ...... insights into dNTP regulation.
@nl
prefLabel
Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
@ast
Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
@en
Structures of eukaryotic ribon ...... insights into dNTP regulation.
@nl
P2093
P2860
P356
P1476
Structures of eukaryotic ribon ...... insights into dNTP regulation.
@en
P2093
Catherine Faber
Chris Dealwis
James W Fairman
Joseph Racca
Tomoaki Uchiki
P2860
P304
P356
10.1073/PNAS.0600443103
P407
P577
2006-03-14T00:00:00Z